Detailed information of TA system TA151968

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 1895082..1895656
• Replicon: chromosome
• Accession: NZ_CP049980
• Organism: Leclercia adecarboxylata strain 707804

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: G7098_RS08890
• Protein ID: WP_103792339.1
• Coordinates: 1895330..1895656 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A6G7TED5
• Locus tag: G7098_RS08885
• Protein ID: WP_059307895.1
• Coordinates: 1895082..1895330 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7098_RS08870	1891985..1893529	+	1545	WP_059307898.1	nitrate reductase subunit beta	-
G7098_RS08875	1893529..1894224	+	696	WP_165717853.1	nitrate reductase molybdenum cofactor assembly chaperone	-
G7098_RS08880	1894221..1894901	+	681	WP_032618185.1	respiratory nitrate reductase subunit gamma	-
G7098_RS08885	1895082..1895330	+	249	WP_059307895.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
G7098_RS08890	1895330..1895656	+	327	WP_103792339.1	endoribonuclease MazF	Toxin
G7098_RS08895	1895745..1896194	-	450	WP_165717854.1	hypothetical protein	-
G7098_RS08900	1896428..1897273	-	846	WP_165717855.1	N-hydroxyarylamine O-acetyltransferase	-
G7098_RS08905	1897470..1899125	-	1656	WP_163603428.1	iron ABC transporter permease	-
G7098_RS08910	1899164..1900132	-	969	WP_117386488.1	ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-107)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 11861.62 Da
• Isoelectric Point: 7.8831

>T151968 WP_103792339.1 NZ_CP049980:1895330-1895656 [Leclercia adecarboxylata]
MDYIPEAGDIVWLDFDPQSGHEQAGHRPALVVSPATYNGRTGLMLCCPVTSQIKNYPFEVVISGARRNVALADQIKSLDW
RARHAVKKGTATAEELDAVRMRAKVLIG

Nucleotide

• Length: 327 bp

>T151968 NZ_CP065857:c2176278-2176069 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9137.39 Da
• Isoelectric Point: 4.4777

>AT151968 WP_059307895.1 NZ_CP049980:1895082-1895330 [Leclercia adecarboxylata]
MPQVTVKKWGNSPSVRLPVAVMREAELHVDDVVNVNVDEEGRIILTPVRKDEPTLESLLAAITDDNLHHEVTFGEPQGKE
LL

Nucleotide

• Length: 249 bp

>AT151968 NZ_CP065857:c2176583-2176290 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Antitoxin

• AlphaFold DB: A0A6G7TED5