Detailed information of TA system TA151967

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1817111..1818649
• Replicon: chromosome
• Accession: NZ_CP049980
• Organism: Leclercia adecarboxylata strain 707804

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: G7098_RS08575
• Protein ID: WP_165717821.1
• Coordinates: 1817111..1818394 (-)
• Length: 428 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: G7098_RS08580
• Protein ID: WP_032618098.1
• Coordinates: 1818398..1818649 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7098_RS08560	1812592..1813773	-	1182	WP_032618094.1	PLP-dependent aminotransferase family protein	-
G7098_RS08565	1813906..1815903	-	1998	WP_165717820.1	TonB-dependent receptor	-
G7098_RS08570	1815914..1816975	-	1062	WP_163603397.1	YncE family protein	-
G7098_RS08575	1817111..1818394	-	1284	WP_165717821.1	type II toxin-antitoxin system HipA family toxin	Toxin
G7098_RS08580	1818398..1818649	-	252	WP_032618098.1	helix-turn-helix domain-containing protein	Antitoxin
G7098_RS08585	1819449..1823249	+	3801	WP_165717822.1	glycosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 428 a.a.
• Molecular weight: 47098.03 Da
• Isoelectric Point: 6.6978

>T151967 WP_165717821.1 NZ_CP049980:c1818394-1817111 [Leclercia adecarboxylata]
MRAQRLTVAMNGDVVGTLHRDGSGAMSFQYAPEWLAEPGSRAISLSLPLQHGRIRGAQVFNFFSNLLPDSEAIIARMQAR
FQVETAHPSDLLASVGRDCVGAIQLYPPGQEIPPVTDIVAEPLDDDQIAALLDGYQMAPLGMTEEDADFRISLAGAQEKT
ALLWYQARWQRPQGSTPTSHIFKLPIGRIEQNNIDLSESCENEWLCLRIAKAFGFPVAQAEMATFGRKKVLIIERFDRRW
SSSGWLMRLPQEDFCQALGVSPALKYESHGGPGIADAIKLLLGSRLAGQDRELFFKAQILFWMLAAIDGHGKNFSLFIEA
DSAFRMAPLFDAGGIPVKKAKMAMALQGKNRQYHFAMIQPRHFISTAAFAGYSQEAARRLLAEMAERTDDVIASVRAELP
PDFPAQVSEAIFKGLASQAARIGRFVS

Nucleotide

• Length: 1284 bp

>T151967 NZ_CP065857:c2156673-2156311 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9223.56 Da
• Isoelectric Point: 10.1945

>AT151967 WP_032618098.1 NZ_CP049980:c1818649-1818398 [Leclercia adecarboxylata]
MKVTSADALAQAVRDQRKVNKLTQTATAEQVGIKQTTVSEFENKPGSTKLETLFKILSALDLELHVVKRGGTLPDNNAWK
KEW

Nucleotide

• Length: 252 bp

>AT151967 NZ_CP065857:c2156840-2156670 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA