Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 675116..675735 Replicon chromosome
Accession NZ_CP049980
Organism Leclercia adecarboxylata strain 707804

Toxin (Protein)


Gene name Hha Uniprot ID A0A345CDT0
Locus tag G7098_RS03130 Protein ID WP_032616864.1
Coordinates 675116..675334 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3E1ZZ82
Locus tag G7098_RS03135 Protein ID WP_032616865.1
Coordinates 675343..675735 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7098_RS03110 671960..672313 + 354 WP_059308601.1 DUF1428 family protein -
G7098_RS03115 672346..673914 - 1569 WP_165717486.1 EAL domain-containing protein -
G7098_RS03120 674180..674320 + 141 WP_032616862.1 type B 50S ribosomal protein L36 -
G7098_RS03125 674380..674844 - 465 WP_032616863.1 membrane protein -
G7098_RS03130 675116..675334 - 219 WP_032616864.1 hemolysin expression modulator Hha Toxin
G7098_RS03135 675343..675735 - 393 WP_032616865.1 Hha toxicity modulator TomB Antitoxin
G7098_RS03140 676226..679366 - 3141 WP_059308599.1 multidrug efflux RND transporter permease subunit AcrB -
G7098_RS03145 679389..680582 - 1194 WP_032616867.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 663959..675735 11776


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T151965 WP_032616864.1 NZ_CP049980:c675334-675116 [Leclercia adecarboxylata]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Download         Length: 219 bp

>T151965 NZ_CP065857:c1994394-1994242 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15093.98 Da        Isoelectric Point: 4.8941

>AT151965 WP_032616865.1 NZ_CP049980:c675735-675343 [Leclercia adecarboxylata]
MDEYSPKRQDIAQLKFLCESLYHDCLSNLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNASKANPLASPVKIITNN

Download         Length: 393 bp

>AT151965 NZ_CP065857:c1995018-1994419 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCTAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATATTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A345CDT0

Antitoxin

Source ID Structure
AlphaFold DB A0A3E1ZZ82

References