Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 347873..348516 Replicon chromosome
Accession NZ_CP049980
Organism Leclercia adecarboxylata strain 707804

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag G7098_RS01620 Protein ID WP_015387203.1
Coordinates 347873..348289 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A3E1ZVJ5
Locus tag G7098_RS01625 Protein ID WP_032616516.1
Coordinates 348286..348516 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7098_RS01600 343896..344486 - 591 WP_059308736.1 TetR/AcrR family transcriptional regulator -
G7098_RS01605 344611..345486 - 876 WP_059308735.1 NmrA family NAD(P)-binding protein -
G7098_RS01610 345730..346635 - 906 WP_165717411.1 SDR family oxidoreductase -
G7098_RS01615 346778..347674 + 897 WP_059308733.1 AraC family transcriptional regulator -
G7098_RS01620 347873..348289 - 417 WP_015387203.1 type II toxin-antitoxin system VapC family toxin Toxin
G7098_RS01625 348286..348516 - 231 WP_032616516.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
G7098_RS01630 348920..349072 + 153 WP_059308732.1 Hok/Gef family protein -
G7098_RS01635 349164..349769 - 606 WP_144838943.1 3-isopropylmalate dehydratase small subunit -
G7098_RS01640 349780..351180 - 1401 WP_151583595.1 3-isopropylmalate dehydratase large subunit -
G7098_RS01645 351183..352274 - 1092 WP_059308730.1 3-isopropylmalate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14924.31 Da        Isoelectric Point: 7.2449

>T151964 WP_015387203.1 NZ_CP049980:c348289-347873 [Leclercia adecarboxylata]
VIKTYMLDTNICSFIMREQPEAVIKRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPRHGLLVEAFCARLDAILAWDRA
AVDATTEIKAALTAAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWAN

Download         Length: 417 bp

>T151964 NZ_CP065857:1900691-1900786 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8687.72 Da        Isoelectric Point: 4.4563

>AT151964 WP_032616516.1 NZ_CP049980:c348516-348286 [Leclercia adecarboxylata]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFTQLEKADSDFMSERGDVVSDEGRFDL

Download         Length: 231 bp

>AT151964 NZ_CP065857:c1900873-1900814 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3E1ZVJ5

References