Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3693548..3694029 Replicon chromosome
Accession NZ_CP049979
Organism Escherichia coli strain IBS28

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7YS45
Locus tag HAP53_RS17760 Protein ID WP_014966210.1
Coordinates 3693739..3694029 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A0P7NPJ2
Locus tag HAP53_RS17755 Protein ID WP_000100895.1
Coordinates 3693548..3693739 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAP53_RS17705 3688768..3688944 - 177 WP_000753060.1 hypothetical protein -
HAP53_RS17710 3688937..3689119 - 183 WP_001224672.1 hypothetical protein -
HAP53_RS17715 3689267..3689572 - 306 WP_044808070.1 DUF4406 domain-containing protein -
HAP53_RS17720 3689569..3689850 - 282 WP_062877284.1 hypothetical protein -
HAP53_RS17725 3689847..3690644 - 798 WP_062877281.1 DUF1627 domain-containing protein -
HAP53_RS17730 3690678..3691220 - 543 WP_158003628.1 replication protein -
HAP53_RS17735 3691132..3692169 - 1038 WP_062876881.1 hypothetical protein -
HAP53_RS17740 3692238..3692663 - 426 WP_000693925.1 Rha family transcriptional regulator -
HAP53_RS17745 3692647..3692922 - 276 WP_042969575.1 helix-turn-helix domain-containing protein -
HAP53_RS17750 3693030..3693530 + 501 WP_000824162.1 helix-turn-helix transcriptional regulator -
HAP53_RS17755 3693548..3693739 + 192 WP_000100895.1 hypothetical protein Antitoxin
HAP53_RS17760 3693739..3694029 + 291 WP_014966210.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HAP53_RS17765 3694297..3694449 + 153 WP_062863539.1 DUF1391 family protein -
HAP53_RS17770 3694461..3694862 + 402 WP_062863541.1 hypothetical protein -
HAP53_RS17780 3695664..3695852 + 189 WP_000449173.1 cell division inhibitor -
HAP53_RS17785 3695849..3696037 + 189 WP_033885206.1 DUF1482 family protein -
HAP53_RS17790 3696130..3698574 + 2445 WP_155955711.1 exonuclease -
HAP53_RS17795 3698633..3698836 + 204 WP_000096347.1 DUF4224 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3646874..3732253 85379


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11176.05 Da        Isoelectric Point: 9.9854

>T151956 WP_014966210.1 NZ_CP049979:3693739-3694029 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTASNIE
IVNVVHSRRQYPNKTC

Download         Length: 291 bp

>T151956 NZ_CP065848:2755038-2755793 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGTGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATGCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAACTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7003.80 Da        Isoelectric Point: 4.0270

>AT151956 WP_000100895.1 NZ_CP049979:3693548-3693739 [Escherichia coli]
MSTALSPIISEFETVEQENSYNEWLRAKVAASLSDPRPAIPHDEVMAEMENLIAQLAATNRSE

Download         Length: 192 bp

>AT151956 NZ_CP065848:2754535-2754903 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCACCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7YS45

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7NPJ2

References