Detailed information of TA system TA151931

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 2362950..2363928
• Replicon: chromosome
• Accession: NZ_CP049978
• Organism: Bacillus sp. RZ2MS9

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: W8Y388
• Locus tag: BHV55_RS12200
• Protein ID: WP_000624977.1
• Coordinates: 2362950..2363687 (+)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: W8YZL5
• Locus tag: BHV55_RS12205
• Protein ID: WP_000237818.1
• Coordinates: 2363800..2363928 (+)
• Length: 43 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BHV55_RS12180	2358593..2359375	+	783	WP_000381800.1	class I SAM-dependent methyltransferase	-
BHV55_RS12185	2359533..2361218	-	1686	WP_070758101.1	alpha-keto acid decarboxylase family protein	-
BHV55_RS12190	2361326..2361808	+	483	WP_000191888.1	MarR family winged helix-turn-helix transcriptional regulator	-
BHV55_RS12195	2361975..2362712	+	738	WP_000594152.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
BHV55_RS12200	2362950..2363687	+	738	WP_000624977.1	stage II sporulation protein SA	Toxin
BHV55_RS12205	2363800..2363928	+	129	WP_000237818.1	hypothetical protein	Antitoxin
BHV55_RS12210	2364001..2364177	+	177	WP_000852629.1	stage II sporulation protein SB	-
BHV55_RS12215	2364196..2364585	-	390	WP_000713866.1	YxeA family protein	-
BHV55_RS12220	2364797..2366266	+	1470	WP_000287515.1	beta-Ala-His dipeptidase	-
BHV55_RS12225	2366512..2367321	+	810	WP_000678509.1	C39 family peptidase	-
BHV55_RS12230	2367347..2367949	+	603	WP_000517260.1	hypothetical protein	-
BHV55_RS12235	2368189..2368440	-	252	WP_000827560.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (10-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28307.03 Da
• Isoelectric Point: 8.2998

>T151931 WP_000624977.1 NZ_CP049978:2362950-2363687 [Bacillus sp. RZ2MS9]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T151931 NZ_CP065839:41161-41643 [Klebsiella quasipneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGACTTAAGTCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 43 a.a.
• Molecular weight: 5011.40 Da
• Isoelectric Point: 3.9150

>AT151931 WP_000237818.1 NZ_CP049978:2363800-2363928 [Bacillus sp. RZ2MS9]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS

Nucleotide

• Length: 129 bp

>AT151931 NZ_CP065839:40907-41173 [Klebsiella quasipneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCCCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Toxin

• AlphaFold DB: W8Y388

Antitoxin

• AlphaFold DB: W8YZL5