Detailed information of TA system TA151917

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 2665586..2666574
• Replicon: chromosome
• Accession: NZ_CP049967
• Organism: Escherichia coli strain ARL09/232

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: G9448_RS13165
• Protein ID: WP_014640052.1
• Coordinates: 2665586..2665972 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A0J5Z6D5
• Locus tag: G9448_RS13170
• Protein ID: WP_000458584.1
• Coordinates: 2666002..2666574 (-)
• Length: 191 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9448_RS13110	2660664..2661029	+	366	WP_001374361.1	ClpX C4-type zinc finger	-
G9448_RS13115	2661372..2662289	+	918	Protein_2567	recombination-associated protein RdgC	-
G9448_RS13120	2662398..2662937	+	540	WP_000120456.1	hypothetical protein	-
G9448_RS13125	2662925..2663101	+	177	WP_175565498.1	hypothetical protein	-
G9448_RS13130	2663098..2663352	+	255	WP_048216132.1	hypothetical protein	-
G9448_RS13135	2663349..2663693	+	345	WP_048216131.1	hypothetical protein	-
G9448_RS13140	2663686..2664156	+	471	WP_176607987.1	DUF550 domain-containing protein	-
G9448_RS13145	2664159..2664413	+	255	WP_000492059.1	DUF4222 domain-containing protein	-
G9448_RS13150	2664435..2665007	+	573	WP_097475728.1	3'-5' exoribonuclease	-
G9448_RS13155	2665044..2665325	+	282	WP_001093916.1	pyocin activator PrtN family protein	-
G9448_RS13160	2665373..2665546	-	174	WP_000390072.1	hypothetical protein	-
G9448_RS13165	2665586..2665972	-	387	WP_014640052.1	hypothetical protein	Toxin
G9448_RS13170	2666002..2666574	-	573	WP_000458584.1	SocA family protein	Antitoxin
G9448_RS13175	2666810..2666932	-	123	WP_001300034.1	hypothetical protein	-
G9448_RS13180	2667296..2668318	-	1023	WP_000912602.1	DUF2713 family protein	-
G9448_RS13185	2668636..2669151	+	516	WP_001295691.1	zinc uptake transcriptional repressor Zur	-
G9448_RS13190	2669193..2669402	-	210	WP_001030593.1	CsbD family protein	-
G9448_RS13195	2669518..2670843	-	1326	WP_001295692.1	MATE family efflux transporter DinF	-
G9448_RS13200	2670916..2671524	-	609	WP_000646078.1	transcriptional repressor LexA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2625239..2671524	46285

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-137)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T151917 WP_014640052.1 NZ_CP049967:c2665972-2665586 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T151917 NZ_CP065833:c5029058-5028675 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 191 a.a.
• Molecular weight: 21973.21 Da
• Isoelectric Point: 6.0283

>AT151917 WP_000458584.1 NZ_CP049967:c2666574-2666002 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHNVSLRSDPREMDADEVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Nucleotide

• Length: 573 bp

>AT151917 NZ_CP065833:c5029300-5029058 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A0J5Z6D5