Detailed information of TA system TA151914

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 2347013..2347833
• Replicon: chromosome
• Accession: NZ_CP049967
• Organism: Escherichia coli strain ARL09/232

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: G9448_RS11490
• Protein ID: WP_001054379.1
• Coordinates: 2347013..2347270 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: G9448_RS11495
• Protein ID: WP_000123957.1
• Coordinates: 2347282..2347833 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9448_RS11470	2342300..2343406	+	1107	WP_001295733.1	N-acetylneuraminate epimerase	-
G9448_RS11475	2343470..2344450	+	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
G9448_RS11480	2345033..2346259	-	1227	Protein_2245	DNA helicase	-
G9448_RS11485	2346337..2346636	+	300	WP_001332034.1	GNAT family N-acetyltransferase	-
G9448_RS11490	2347013..2347270	+	258	WP_001054379.1	YjhX family toxin	Toxin
G9448_RS11495	2347282..2347833	+	552	WP_000123957.1	N-acetyltransferase	Antitoxin
G9448_RS11500	2347885..2348631	+	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
G9448_RS11505	2348759..2349019	+	261	WP_000077646.1	hypothetical protein	-
G9448_RS11510	2349418..2350539	+	1122	WP_000010833.1	M42 family metallopeptidase	-
G9448_RS11515	2350536..2350814	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
G9448_RS11520	2350826..2352139	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T151914 WP_001054379.1 NZ_CP049967:2347013-2347270 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T151914 NZ_CP065833:c4444983-4444450 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT151914 WP_000123957.1 NZ_CP049967:2347282-2347833 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT151914 NZ_CP065833:c4445260-4444994 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: B6I030