Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 4593899..4594547 Replicon chromosome
Accession NZ_CP049956
Organism Stenotrophomonas maltophilia strain NCTC10498

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag G6Z48_RS21570 Protein ID WP_165711185.1
Coordinates 4593899..4594204 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag G6Z48_RS21575 Protein ID WP_005407703.1
Coordinates 4594245..4594547 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6Z48_RS21540 4589853..4590644 - 792 WP_165711184.1 zinc-dependent peptidase -
G6Z48_RS21545 4590611..4590889 - 279 WP_049460449.1 hypothetical protein -
G6Z48_RS21550 4591034..4591999 + 966 WP_043035430.1 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor -
G6Z48_RS21555 4591996..4592727 + 732 WP_005407698.1 type III pantothenate kinase -
G6Z48_RS21560 4592737..4593591 + 855 WP_005411958.1 SPOR domain-containing protein -
G6Z48_RS21570 4593899..4594204 + 306 WP_165711185.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6Z48_RS21575 4594245..4594547 + 303 WP_005407703.1 putative addiction module antidote protein Antitoxin
G6Z48_RS21580 4594782..4595104 - 323 Protein_4231 hypothetical protein -
G6Z48_RS21585 4595185..4595592 - 408 WP_165711186.1 hypothetical protein -
G6Z48_RS21590 4596187..4596957 + 771 WP_165711187.1 DUF3011 domain-containing protein -
G6Z48_RS21595 4596982..4597329 - 348 WP_165711188.1 hypothetical protein -
G6Z48_RS21600 4597460..4598380 + 921 WP_005407709.1 arginase -
G6Z48_RS21605 4598541..4598678 + 138 WP_005407710.1 entericidin A/B family lipoprotein -
G6Z48_RS21610 4598716..4598895 - 180 WP_164225318.1 hypothetical protein -
G6Z48_RS21615 4598882..4599103 + 222 WP_004153772.1 CsbD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-95)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11372.08 Da        Isoelectric Point: 11.2113

>T151879 WP_165711185.1 NZ_CP049956:4593899-4594204 [Stenotrophomonas maltophilia]
MKIQRTRQFATWIDALKDVTARARILARIGRLAEGHPGDHRYLADGVSGLRIDAGPGYRVYYTQRGRQLVILLVGGDKGS
QQRDIEKAKEIARALRASNWL

Download         Length: 306 bp

>T151879 NZ_CP065824:5399596-5399850 [Pseudomonas tolaasii]
ATGGAAACCATCAACTACACCAACGCACGCGCTCATCTGGCTGAAACGATGGACCGCGTCAACGAAGATCGCATCCCACT
GTTACTTACGCGCCAAAAAGGTGAGCCCGTGGTGATGATCTCATTATCAGAATTCAACGCTCTTGAAGAGACAGCCTACC
TGCTGCGCTCACCTAAAAATGCCGAACGCCTGATCAACTCCGTCAATAGCTTGCGGGCCGGCAAAGCCAAACCCAGGGGG
CTGATTGAGGAATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10703.27 Da        Isoelectric Point: 7.2780

>AT151879 WP_005407703.1 NZ_CP049956:4594245-4594547 [Stenotrophomonas maltophilia]
MAIKKKVELEAFDVAEHLHTPKEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPD
FSTILKVTRALGVRLHASAA

Download         Length: 303 bp

>AT151879 NZ_CP065824:5399847-5400101 [Pseudomonas tolaasii]
ATGAAAATACTCTTTACCCCTGAAGGCTGGGACGACTATCTCTGGTTTCAACAGAATGACAAGACAGGGTTAAAGCGTAT
AAACCTGCTGATCAAAGCCATCCAGAGAGACCCTTTTGAAGGCGTTGGGAAACCGGAACCGCTCAAGCACAACCTGAGCG
GTTTCTGGTCACGGCGTATCACCGCAGAACATCGCCTCGTTTATGGCATTGAGGACGATGAAGTACAGATCCTGATGTGT
CGCTATCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References