Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 1120613..1121655 | Replicon | chromosome |
| Accession | NZ_CP049956 | ||
| Organism | Stenotrophomonas maltophilia strain NCTC10498 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | G6Z48_RS05330 | Protein ID | WP_003153636.1 |
| Coordinates | 1121080..1121655 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | I3TV68 |
| Locus tag | G6Z48_RS05325 | Protein ID | WP_003050245.1 |
| Coordinates | 1120613..1121083 (+) | Length | 157 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G6Z48_RS05290 | 1115989..1117407 | - | 1419 | WP_003821113.1 | TIGR03752 family integrating conjugative element protein | - |
| G6Z48_RS05295 | 1117397..1118311 | - | 915 | WP_165710335.1 | TIGR03749 family integrating conjugative element protein | - |
| G6Z48_RS05300 | 1118308..1119000 | - | 693 | WP_012614071.1 | TIGR03746 family integrating conjugative element protein | - |
| G6Z48_RS05305 | 1118997..1119407 | - | 411 | WP_165710336.1 | TIGR03750 family conjugal transfer protein | - |
| G6Z48_RS05310 | 1119420..1119779 | - | 360 | WP_165710337.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| G6Z48_RS05315 | 1119796..1120029 | - | 234 | WP_003050225.1 | TIGR03758 family integrating conjugative element protein | - |
| G6Z48_RS05320 | 1120026..1120409 | - | 384 | WP_003090167.1 | RAQPRD family integrative conjugative element protein | - |
| G6Z48_RS05325 | 1120613..1121083 | + | 471 | WP_003050245.1 | helix-turn-helix domain-containing protein | Antitoxin |
| G6Z48_RS05330 | 1121080..1121655 | + | 576 | WP_003153636.1 | PIN domain-containing protein | Toxin |
| G6Z48_RS05335 | 1121673..1122587 | + | 915 | WP_003050256.1 | AAA family ATPase | - |
| G6Z48_RS05340 | 1122584..1123054 | + | 471 | WP_003153638.1 | hypothetical protein | - |
| G6Z48_RS05345 | 1123051..1123551 | + | 501 | WP_003090159.1 | hypothetical protein | - |
| G6Z48_RS05350 | 1123551..1124453 | + | 903 | WP_003153640.1 | nucleotidyltransferase domain-containing protein | - |
| G6Z48_RS05355 | 1124492..1125217 | + | 726 | WP_003050273.1 | CBASS effector endonuclease NucC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1069657..1171182 | 101525 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21629.78 Da Isoelectric Point: 5.9995
>T151877 WP_003153636.1 NZ_CP049956:1121080-1121655 [Stenotrophomonas maltophilia]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T151877 NZ_CP065824:3803225-3803476 [Pseudomonas tolaasii]
GTGTCCAAAAATGAAAAGCTGCTGGCCAAATTGCTCAATGCGCAAATGGCATTCACCTGGCCCGAGCTGGTAACGCTTCT
GCTCCGACTGGGTTACACACAAATTGAGGGGGCAGGAAGCCGGGTCAAGTTCGACATCGGCGACCCCAGTGCAATGATCA
CACTGCACAAGCCCCACCCTGGCAACGAACTGAAACACTACATTCGGCGCCAGATCATCGAACAATTGAAATCAGGAGAA
CTGATTCAGTGA
GTGTCCAAAAATGAAAAGCTGCTGGCCAAATTGCTCAATGCGCAAATGGCATTCACCTGGCCCGAGCTGGTAACGCTTCT
GCTCCGACTGGGTTACACACAAATTGAGGGGGCAGGAAGCCGGGTCAAGTTCGACATCGGCGACCCCAGTGCAATGATCA
CACTGCACAAGCCCCACCCTGGCAACGAACTGAAACACTACATTCGGCGCCAGATCATCGAACAATTGAAATCAGGAGAA
CTGATTCAGTGA
Antitoxin
Download Length: 157 a.a. Molecular weight: 17245.62 Da Isoelectric Point: 6.3803
>AT151877 WP_003050245.1 NZ_CP049956:1120613-1121083 [Stenotrophomonas maltophilia]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT151877 NZ_CP065824:3803473-3803838 [Pseudomonas tolaasii]
GTGAACAACCAACTGAAACACAACGGCTACATCGGCTCGATAGAAGCCAGCCTCGAAGACGATTGCCTGTTCGGCAAGGT
GCTGTTTATCAAGGCGCTGGTCAGCTATGAGGGGAAAACCGTGGCCGAACTGGATGCGGCTTTTCGCGAAGCCGTAGACG
ACTACCTCGCCACGTGCATGAGCCTGGGGCAAGCACCGGAAAAACCCTGCAAGGGCTCGTTCAACGTACGGGTCGGCCAT
GACCTGCACCTGGCCGCGGCTCTGGAGGCGACCCGTAAAAAAGTGACGCTGAACGATTTGACCCGCCAGGCCTTGAGCGA
ATTTCTGCAACACCACAGTGTGGCTTCCAGCCCGGCGGCCGGCTGA
GTGAACAACCAACTGAAACACAACGGCTACATCGGCTCGATAGAAGCCAGCCTCGAAGACGATTGCCTGTTCGGCAAGGT
GCTGTTTATCAAGGCGCTGGTCAGCTATGAGGGGAAAACCGTGGCCGAACTGGATGCGGCTTTTCGCGAAGCCGTAGACG
ACTACCTCGCCACGTGCATGAGCCTGGGGCAAGCACCGGAAAAACCCTGCAAGGGCTCGTTCAACGTACGGGTCGGCCAT
GACCTGCACCTGGCCGCGGCTCTGGAGGCGACCCGTAAAAAAGTGACGCTGAACGATTTGACCCGCCAGGCCTTGAGCGA
ATTTCTGCAACACCACAGTGTGGCTTCCAGCCCGGCGGCCGGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|