Detailed information of TA system TA151875

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5012456..5014137
• Replicon: chromosome
• Accession: NZ_CP049953
• Organism: Klebsiella pneumoniae strain 19KM1109

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: W8V1Q6
• Locus tag: G9175_RS24715
• Protein ID: WP_002885155.1
• Coordinates: 5012456..5013373 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: W8UPQ8
• Locus tag: G9175_RS24720
• Protein ID: WP_004151732.1
• Coordinates: 5013379..5014137 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9175_RS24695	5007762..5009282	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
G9175_RS24700	5009279..5010277	+	999	WP_002885172.1	ribose ABC transporter permease	-
G9175_RS24705	5010308..5011249	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
G9175_RS24710	5011324..5012331	+	1008	WP_004151731.1	carbohydrate kinase family protein	-
G9175_RS24715	5012456..5013373	-	918	WP_002885155.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
G9175_RS24720	5013379..5014137	-	759	WP_004151732.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
G9175_RS24725	5014223..5014951	-	729	WP_002885152.1	response regulator transcription factor	-
G9175_RS24730	5015224..5017371	+	2148	WP_077598858.1	formate dehydrogenase subunit alpha	-
G9175_RS24735	5017601..5018287	+	687	WP_176817335.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34687.15 Da
• Isoelectric Point: 5.4707

>T151875 WP_002885155.1 NZ_CP049953:c5013373-5012456 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T151875 NZ_CP065824:1919248-1919436 [Pseudomonas tolaasii]
GTGCAAAGCAGGTTATTGATCAAGGAGCTGCAAGAGGCGGGCTGGGTGCTGGATCGAGTTACCGGCAGTCATCATATTTT
CACTCACCGTTACAGCCCGTACACGATCCCGGTGCCCCATCCCAAGAAGGACTTGCCGCTGGGCACCGTTCGAAGCATCA
GGAAACGCGCCGGTTTGTTTGAGTTTTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28564.92 Da
• Isoelectric Point: 10.0870

>AT151875 WP_004151732.1 NZ_CP049953:c5014137-5013379 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT151875 NZ_CP065824:1919448-1919852 [Pseudomonas tolaasii]
ATGCAATACCCAATCTGTATCGAATGGGGCGATGACTTTACCGCCACCGGCATTCAGATCCCTGACATTCCGGGCGCAGT
CACCGCCGGGGACAGTTTTGAAGAGGCATACAACGCCGCCGTGGAAGTGGCGCACATCATGTTGCAGGAGATTGCAGCAG
AAGGCGGGCCGATTCCGATGCCAACGTCAGTCGCCAATCACCACGCCCATGAGGACTACGCGGGCATGGGCTGGGGCATG
CTGGAGCTGGACATCTCGCCCTATCTGGGCAAAACCGAGAAGGTCAATGTGACCTTGCCCGGTTATGTCATCCAGCGCAT
CGACCGCTATGTGCGCGAGCACAAGGTCAAAAGCCGCTCGTCCTTTCTGGCGGATGCGGCGTTGGAGAAGTTGGTGCGTT
CGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3GH11

Antitoxin

• AlphaFold DB: A0A0H3GQB5