Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4854966..4855482 Replicon chromosome
Accession NZ_CP049953
Organism Klebsiella pneumoniae strain 19KM1109

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag G9175_RS23910 Protein ID WP_002886902.1
Coordinates 4854966..4855250 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag G9175_RS23915 Protein ID WP_002886901.1
Coordinates 4855240..4855482 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9175_RS23885 4850450..4850758 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
G9175_RS23890 4850843..4851016 + 174 WP_002886906.1 hypothetical protein -
G9175_RS23895 4851019..4851762 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
G9175_RS23900 4852119..4854257 + 2139 WP_042943710.1 anaerobic ribonucleoside-triphosphate reductase -
G9175_RS23905 4854498..4854962 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
G9175_RS23910 4854966..4855250 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G9175_RS23915 4855240..4855482 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
G9175_RS23920 4855560..4857470 - 1911 WP_004152270.1 BglG family transcription antiterminator -
G9175_RS23925 4857493..4858647 - 1155 WP_002886900.1 lactonase family protein -
G9175_RS23930 4858713..4859453 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T151874 WP_002886902.1 NZ_CP049953:c4855250-4854966 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T151874 NZ_CP065824:c1626476-1626189 [Pseudomonas tolaasii]
ATGACCTATAGCCTCGATTTTGATGCCCGCGCATTGAAGGAATGGCAAAAACTCGGCGACACCGTCCGTCAGCAGCTCAA
GAAGAAGTTGGTGGAAATCCTGAAAAATCCACGCGTTGAAACTAACCGCCTGCATGGCCTGCCGGACTGTTACAAGATAA
AGCTGCGTAGCAGTGGTTACAGGCTGGTTTATCAAGTGATTGATCAGGAAATTACCGTGTTTGTGGTGGCCGTAGATAAA
CGGGAGCGTGATCAGGTTTATCAGAAGGCATCCGAGCGATTGAGCTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT151874 WP_002886901.1 NZ_CP049953:c4855482-4855240 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT151874 NZ_CP065824:c1626705-1626466 [Pseudomonas tolaasii]
ATGGCCTCCATCAATATTCGAATCGACGACGACCTGAAAGCTCGCGCCTACCTTGAACTGGAAAAACTCGGCGTCACGCC
TTCCGAACTCATGCGCCAAGCGCTGCAGTATGTGGCAGACCGTGGTCAGTTGCCCTTCAAGCCGGTGCTGATGACTGAGG
ACGATGAAGCCCTGATGGCCACTGTGCGAGAACGACTGGCGTCTCCTCAACGCGTAAAGGTTTCCATAGATGACCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References