Detailed information of TA system TA151873

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4759680..4760515
• Replicon: chromosome
• Accession: NZ_CP049953
• Organism: Klebsiella pneumoniae strain 19KM1109

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A5E2RWI0
• Locus tag: G9175_RS23520
• Protein ID: WP_001559913.1
• Coordinates: 4759680..4760057 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A5E3EVB5
• Locus tag: G9175_RS23525
• Protein ID: WP_032408847.1
• Coordinates: 4760147..4760515 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9175_RS23480	4755141..4755815	+	675	WP_004152211.1	hypothetical protein	-
G9175_RS23485	4755827..4756165	+	339	WP_064449948.1	hypothetical protein	-
G9175_RS23490	4756168..4756647	+	480	WP_002887049.1	type VI secretion system tube protein Hcp	-
G9175_RS23495	4756839..4757162	-	324	Protein_4608	superfamily I DNA helicase	-
G9175_RS23500	4757181..4758292	-	1112	Protein_4609	IS3 family transposase	-
G9175_RS23505	4758741..4758893	-	153	WP_164713811.1	hypothetical protein	-
G9175_RS23510	4758978..4759265	-	288	WP_073970535.1	DUF957 domain-containing protein	-
G9175_RS23515	4759195..4759683	-	489	WP_001559914.1	hypothetical protein	-
G9175_RS23520	4759680..4760057	-	378	WP_001559913.1	TA system toxin CbtA family protein	Toxin
G9175_RS23525	4760147..4760515	-	369	WP_032408847.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
G9175_RS23530	4760692..4760913	-	222	WP_000692300.1	DUF987 domain-containing protein	-
G9175_RS23535	4760982..4761458	-	477	WP_032408846.1	RadC family protein	-
G9175_RS23540	4761473..4761958	-	486	WP_088607457.1	antirestriction protein	-
G9175_RS23545	4762050..4762868	-	819	WP_001559911.1	DUF945 domain-containing protein	-
G9175_RS23550	4762968..4763201	-	234	WP_001119729.1	DUF905 family protein	-
G9175_RS23555	4763280..4763735	-	456	WP_000581504.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14148.10 Da
• Isoelectric Point: 7.8276

>T151873 WP_001559913.1 NZ_CP049953:c4760057-4759680 [Klebsiella pneumoniae]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Nucleotide

• Length: 378 bp

>T151873 NZ_CP065824:961907-962182 [Pseudomonas tolaasii]
ATGGAATTGAAGTGGACCAGTAAGGCCTTATCCGACCTGGCTCGACTTTTCGACTTCCTTGCCGTTGTAAATCGGATGGC
GGCGGCGCGTACAGTGCAGTCGCTTTCCCAAGCACCTATGAGCTTGGTGAGCAATCCGCGAATAGGTGAACGGGTTGAAG
AATTTGAACCGCGAGACGTGAGAAGGCTATTGGTCGGCCATTACGAAATACGCTACGAAATTCAGGAATCGACGGTCTAC
ATTTTGCGTTTGTGGCATGTCCGCGAAGATCGTTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13682.62 Da
• Isoelectric Point: 7.8398

>AT151873 WP_032408847.1 NZ_CP049953:c4760515-4760147 [Klebsiella pneumoniae]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT151873 NZ_CP065824:961641-961907 [Pseudomonas tolaasii]
ATGGGCGCCGACACAAAAGTACTGACAGCTCACGTCCCCACCGCCCTGGCGCAAAAAGTCGATCAACTCGCGGCGCGAAT
GGACCGATCGCGTGGCTGGATTGTCAAGCAAGCACTCGCCGATTGGGTTGATATGGAGGAAGAGCGCAGTCGACTGACGC
GTGAGGCGATGGCCGATGTCGATGCCGGCCGTGTGATTGATCAACAGGCAGTTCAAGCTTGGGCAGACAGTTTGAGCACC
GATACGCCGCTGCCGGTACCTCGATGA

Structures

Toxin

• AlphaFold DB: A0A5E2RWI0

Antitoxin

• AlphaFold DB: A0A5E3EVB5