Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4113547..4114166 Replicon chromosome
Accession NZ_CP049953
Organism Klebsiella pneumoniae strain 19KM1109

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag G9175_RS20390 Protein ID WP_002892050.1
Coordinates 4113948..4114166 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag G9175_RS20385 Protein ID WP_002892066.1
Coordinates 4113547..4113921 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9175_RS20375 4108699..4109892 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G9175_RS20380 4109915..4113061 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
G9175_RS20385 4113547..4113921 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
G9175_RS20390 4113948..4114166 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
G9175_RS20395 4114325..4114891 + 567 WP_002892030.1 maltose O-acetyltransferase -
G9175_RS20400 4114863..4115003 - 141 WP_004147370.1 hypothetical protein -
G9175_RS20405 4115024..4115494 + 471 WP_002892026.1 YlaC family protein -
G9175_RS20410 4115469..4116920 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
G9175_RS20415 4117021..4117719 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
G9175_RS20420 4117716..4117856 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
G9175_RS20425 4117856..4118119 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T151871 WP_002892050.1 NZ_CP049953:4113948-4114166 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T151871 NZ_CP065820:488527-488916 [Acinetobacter seifertii]
TTGATCAACCAATTGAATTTTAAACTGAAATATAGCCGTTTCTCGATTATATTTCAGTTTTTTATTGGCTTAAGTTTAGC
AGCTCTGTTTTATCAGCTGATACCAATACTCTGGTGGTTGGTTGCGATCTGTTTATTATTTATAAGTTTTATTTTCTTTT
TAAAGCGACCACAGCTCGTTCAAATTGCTTATTTAGATCAGAAATTATGGTCACTTAGCTTTCATTTAGAACAAACAATT
TCTCGAGTAGAGATTTTAAAAATAATTGATTATCAGATTTTCATAGTGGTCTATTTTAAGGGTGATAGAACATTAACTTC
TGTTATTTGGTTTGATCAAATGTCCTTATCTCAATGGAAACAGCTTAAGGCTTTAGAAAAATTCTATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT151871 WP_002892066.1 NZ_CP049953:4113547-4113921 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT151871 NZ_CP065820:488263-488520 [Acinetobacter seifertii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTT
TGACCCGTATGTGAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTGTTTGCTGAATTAGTAGAGCAGGAAG
ATCCTGATTTACTTGACTGGTTTATGGAAGTATCTGAACCGCCGCGTACAGAATTACGTGATTTTATTCATAAATTAAAG
CATTATGTTCATGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References