Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 871473..872130 Replicon chromosome
Accession NZ_CP049953
Organism Klebsiella pneumoniae strain 19KM1109

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag G9175_RS04400 Protein ID WP_002916310.1
Coordinates 871720..872130 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag G9175_RS04395 Protein ID WP_002916312.1
Coordinates 871473..871739 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9175_RS04370 866629..868062 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
G9175_RS04375 868181..868909 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
G9175_RS04380 868959..869270 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
G9175_RS04385 869434..870093 + 660 WP_002916317.1 hemolysin III family protein -
G9175_RS04390 870244..871227 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
G9175_RS04395 871473..871739 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
G9175_RS04400 871720..872130 + 411 WP_002916310.1 protein YgfX Toxin
G9175_RS04405 872137..872658 - 522 WP_002916308.1 flavodoxin FldB -
G9175_RS04410 872759..873655 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
G9175_RS04415 873678..874391 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G9175_RS04420 874397..876130 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T151861 WP_002916310.1 NZ_CP049953:871720-872130 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T151861 NZ_CP065790:c3492095-3491754 [Bacillus velezensis]
ATAAAAGAAGCTTTAAGAAATAATAACTATGAGAAATTAACACCAAAAGAAACAGCTAAGCATAGGAGCAAATTCACATC
AAGTTTGAAAGATAGATTGATTGCAGAATGGGAAGAAAAAACCAATCAAAAGTGGCCTAGATATACAGAAGAGGTTTTTG
ATAAGCATGGAGAAGTTGCCCGAAGTATTGGTCAACCGTACGATGCCCATCATATCATCGAGAACAACTTTGGTGGCCCT
CACGAATGGTGGAATATTCATCCGGCAAAATATCCGGATGAACACCAAGCGGGTATACATGGAAAGGGAGCACCATCAGG
AAAACTTTTTCCAAGGAGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT151861 WP_002916312.1 NZ_CP049953:871473-871739 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT151861 NZ_CP065790:c3491744-3491307 [Bacillus velezensis]
ATGGCTGAATTTGAATTTATAAATCATTTAGAAAATAAAACATATAAGGTACCTGAAGAGGATATATTAAAAGCTGAACA
AAGAATGAACGTAGATATTCCAAATGATTTAAAACAATTATATTTAGAAGTCGGTTATGGTTTTATTAAAGGTGAAAGTG
ATAATGCAATTAATAGGATATTGGGGCCAGGGGCAGTAGCCGACATTAGACTAAGAGAAGGAATTTTTGAGTTTGACCCA
GATTTAGGTGAACTTTATGATGATGAAAATAAACTTATTTTTTTTGAAGTAAACGAGGGTGTTTATATTTCTATAGATTT
ACGATTGGCAAATAATCCAATATTTTATTTTGACACTCAAATAGCTGAATCTTTAGAGGATTTTTTTAAAAAGTTCCTCA
ATGATAATGAATATTATATTGATTTAATTGAGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References