Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4796538..4797373 Replicon chromosome
Accession NZ_CP049950
Organism Klebsiella pneumoniae strain 19KM1053

Toxin (Protein)


Gene name yeeV Uniprot ID A0A5E2RWI0
Locus tag G9174_RS23730 Protein ID WP_001559913.1
Coordinates 4796538..4796915 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A5E3EVB5
Locus tag G9174_RS23735 Protein ID WP_032408847.1
Coordinates 4797005..4797373 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9174_RS23690 4791999..4792673 + 675 WP_004152211.1 hypothetical protein -
G9174_RS23695 4792685..4793023 + 339 WP_064449948.1 hypothetical protein -
G9174_RS23700 4793026..4793505 + 480 WP_002887049.1 type VI secretion system tube protein Hcp -
G9174_RS23705 4793697..4794020 - 324 Protein_4649 superfamily I DNA helicase -
G9174_RS23710 4794039..4795150 - 1112 Protein_4650 IS3 family transposase -
G9174_RS23715 4795599..4795751 - 153 WP_164713811.1 hypothetical protein -
G9174_RS23720 4795836..4796123 - 288 WP_073970535.1 DUF957 domain-containing protein -
G9174_RS23725 4796053..4796541 - 489 WP_001559914.1 hypothetical protein -
G9174_RS23730 4796538..4796915 - 378 WP_001559913.1 TA system toxin CbtA family protein Toxin
G9174_RS23735 4797005..4797373 - 369 WP_032408847.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
G9174_RS23740 4797550..4797771 - 222 WP_000692300.1 DUF987 domain-containing protein -
G9174_RS23745 4797840..4798316 - 477 WP_032408846.1 RadC family protein -
G9174_RS23750 4798331..4798816 - 486 WP_088607457.1 antirestriction protein -
G9174_RS23755 4798908..4799726 - 819 WP_001559911.1 DUF945 domain-containing protein -
G9174_RS23760 4799826..4800059 - 234 WP_001119729.1 DUF905 family protein -
G9174_RS23765 4800138..4800593 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14148.10 Da        Isoelectric Point: 7.8276

>T151853 WP_001559913.1 NZ_CP049950:c4796915-4796538 [Klebsiella pneumoniae]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T151853 NZ_CP065789:2069489-2069581 [Bacillus subtilis]
ATGTCAACATTCCAGGCATTAATGCTAATGCTTGCAATCGGGTCGTTTATAATCGCCCTATTGACGTATATAGAAAAAAT
AGACCTCCCTTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13682.62 Da        Isoelectric Point: 7.8398

>AT151853 WP_032408847.1 NZ_CP049950:c4797373-4797005 [Klebsiella pneumoniae]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT151853 NZ_CP065789:c2069735-2069562 [Bacillus subtilis]
TTACAATACATTACAGTGCATTTCTTTAATGAGAAATGCATAAAATAAAAAAGACCGAGGTGCTACCAACACCCCGGCTC
TGTACAAAAAGTTGCCCATCAAAGGGCTTGCTCGATGTGGTTCTAGGTAGGCCTATCCCTTCAGGTTCTGAGGCTCAAGG
GAGGTCTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E2RWI0

Antitoxin

Source ID Structure
AlphaFold DB A0A5E3EVB5

References