Detailed information of TA system TA151814

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3991786..3993357
• Replicon: chromosome
• Accession: NZ_CP049942
• Organism: Proteus mirabilis strain XH1569

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: G9R00_RS18390
• Protein ID: WP_049213398.1
• Coordinates: 3991786..3993099 (-)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: G9R00_RS18395
• Protein ID: WP_004249771.1
• Coordinates: 3993100..3993357 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9R00_RS18370	3986956..3987759	+	804	WP_004249775.1	energy transducer TonB	-
G9R00_RS18375	3987813..3989774	-	1962	WP_004249774.1	hypothetical protein	-
G9R00_RS18380	3989806..3990735	-	930	WP_004246518.1	metallophosphoesterase	-
G9R00_RS18385	3990920..3991384	-	465	WP_049213396.1	DUF1097 domain-containing protein	-
G9R00_RS18390	3991786..3993099	-	1314	WP_049213398.1	type II toxin-antitoxin system HipA family toxin	Toxin
G9R00_RS18395	3993100..3993357	-	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
G9R00_RS18400	3993506..3994870	-	1365	WP_004246513.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
G9R00_RS18405	3995007..3996647	-	1641	WP_004246512.1	membrane protein insertase YidC	-
G9R00_RS18410	3996650..3996910	-	261	WP_012368639.1	membrane protein insertion efficiency factor YidD	-
G9R00_RS18415	3996874..3997233	-	360	WP_004246510.1	ribonuclease P protein component	-
G9R00_RS18420	3997251..3997394	-	144	WP_004246509.1	50S ribosomal protein L34	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49647.74 Da
• Isoelectric Point: 6.4174

>T151814 WP_049213398.1 NZ_CP049942:c3993099-3991786 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPANIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNDWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T151814 NZ_CP065748:c344796-344350 [Delftia lacustris]
ATGACACGCTACCTGCTGGACACCAACATCGCCAGCCACATCATCAAAGGCGATATCCCTGCCGTGCGCGAACAGCTGGT
TCGCGTACCCATGCACCAGATCGCCGTGTCGGCGGTCACGCAGGCCGAACTGATGTACGGGGTCGCAAAGCGCGGCCACC
CTGCCGGGCTGTCGCTGCGGGTGACAGGATTCCTGGCCCGCGTCGAGGTGCTGCCCTGGACGGCCCAGGTGGCCGATGCC
TACGGCCACCTGCGCGCCGCCTGCGAGGCGACCGGCATCACGCTGGCCTCCATGGACATGATGATTGCCGCGCACGCCCT
GCTCCTGCAGCAGCAGGCCGCGCAGGCCGGCGAGCGCTCGGTGCTGGTCACAAGAGACCGGGTGTTCAGCCGCATTCCCG
AACCCGGACTGGCCATCGCGGACTGGACCACCGGCCCGGCTGGCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT151814 WP_004249771.1 NZ_CP049942:c3993357-3993100 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT151814 NZ_CP065748:c345059-344793 [Delftia lacustris]
GTGACGCAGACTGCCAAGCTTTTCACCACCGGTCGCAGCCAGGCCGTGCGCCTTCCCTATGAATTCCGGTTCGAGGAAAA
AGAGGTCTACATACGTCGCGACCCCGTCACGGGCGACGTGATCCTGTCGCGCCGTCCCGACTCATGGCAAGAGTTCTTTG
CGCTCGACGCCACCACCGACGTGCCGGCCGATTTCATGGACACCGCTGACCGAGCGCAGCCAGAGTCAGGCCGCGATCCG
TTTGCCGACGAAGGCAGTGCGCGATGA

Structures

Antitoxin

• AlphaFold DB: B4F0T9