Detailed information of TA system TA151813

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3705636..3706335
• Replicon: chromosome
• Accession: NZ_CP049942
• Organism: Proteus mirabilis strain XH1569

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: G9R00_RS17115
• Protein ID: WP_004249093.1
• Coordinates: 3705636..3706022 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: G9R00_RS17120
• Protein ID: WP_004246828.1
• Coordinates: 3706015..3706335 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9R00_RS17100	3701655..3702236	-	582	WP_004246833.1	DNA-3-methyladenine glycosylase I	-
G9R00_RS17105	3702487..3703392	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
G9R00_RS17110	3703402..3705474	+	2073	WP_004249094.1	glycine--tRNA ligase subunit beta	-
G9R00_RS17115	3705636..3706022	+	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G9R00_RS17120	3706015..3706335	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
G9R00_RS17125	3706384..3706818	-	435	WP_165708684.1	hypothetical protein	-
G9R00_RS17130	3706811..3707695	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
G9R00_RS17135	3707912..3709198	-	1287	WP_017628657.1	DUF3748 domain-containing protein	-
G9R00_RS17140	3709335..3709952	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
G9R00_RS17145	3710254..3710877	+	624	WP_004246821.1	guanylate kinase	-
G9R00_RS17150	3710932..3711207	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T151813 WP_004249093.1 NZ_CP049942:3705636-3706022 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T151813 NZ_CP065747:c5359461-5359186 [Serratia plymuthica]
ATGCTCGTCATCGAATGGAGTCGATCTGCTCGCCAGGACTTGGCGGATATACTGCTTTTCATTGCCAATGACAATCCTCG
GGCAGCCAGAAAAATGAAGGTGTTAATTTCAGAAGCAATTCTTCCTGCCGCTGAACATCCTCATATTTTTCGCCGTGGCA
GAGTTGATGGCACGCACGAAATCATTGTTCATCCCAATTATCTTCTGATCTACCAAGTGGTTGCCGATCGCATCCGGGTG
ATGCGAGTCCTGCATGCACGCCGACGCTATCCCTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT151813 WP_004246828.1 NZ_CP049942:3706015-3706335 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT151813 NZ_CP065747:c5359659-5359462 [Serratia plymuthica]
ATGGTTATCTTACGCTCGCCTGTTGTCTCAGAATATGAGACACAAGAGCAGACGGAAATCTACGATCGCTGGTTTCGGGA
AAAGGTTCGGGAAGCCATGGATGATCCCCTGCCTGGCATTTCCCATGACGAGGTAATGGCCGAGATGGATGCTCTTATCG
CTGTAGCGGAAGCAAGGAAGAAAACCAAGCAGGTATAA

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97