151812

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3172109..3173130 Replicon chromosome
Accession NZ_CP049942
Organism Proteus mirabilis strain XH1569

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag G9R00_RS14780 Protein ID WP_004249488.1
Coordinates 3172561..3173130 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID B4F2H3
Locus tag G9R00_RS14775 Protein ID WP_004245528.1
Coordinates 3172109..3172561 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9R00_RS14755 3167895..3168425 - 531 WP_004245524.1 RNA pyrophosphohydrolase -
G9R00_RS14760 3168694..3169707 + 1014 WP_121910087.1 thiamine ABC transporter substrate binding subunit -
G9R00_RS14765 3169707..3171287 + 1581 WP_004245526.1 thiamine/thiamine pyrophosphate ABC transporter permease ThiP -
G9R00_RS14770 3171280..3171981 + 702 WP_004245527.1 thiamine ABC transporter ATP-binding protein ThiQ -
G9R00_RS14775 3172109..3172561 + 453 WP_004245528.1 helix-turn-helix domain-containing protein Antitoxin
G9R00_RS14780 3172561..3173130 + 570 WP_004249488.1 PIN domain-containing protein Toxin
G9R00_RS14785 3173246..3175600 + 2355 WP_049199421.1 DNA polymerase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

SinI-like, DNA-binding domain

(80-125)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21600.10 Da        Isoelectric Point: 7.3470

>T151812 WP_004249488.1 NZ_CP049942:3172561-3173130 [Proteus mirabilis]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLAAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKNPP
MTVETFLGCLQKQKLPQFISHLRAFQILL

Download         Length: 570 bp

>T151812 NZ_CP065747:c5064324-5063026 [Serratia plymuthica]
ATGGAAAAGCTACGTGTGGCGTTGAATGGCACCCTTGTTGGGACGCTGGAAAAGCATGCGGGCGGCGCGATGTCGTTTGT
TTACCACGAGGAGTGGCTGGCACAAGCCGGTGCGCGCGCCATTTCGTTATCCCTGCCGCTACAACCAGAACCGTTTCGCG
GTGACGTGGTGTATAACTTCTTCGACAACCTGCTGCCGGACAGCGAGCTTATTCGCAGCCGCCTACAGGCGCGTTTTAGA
ACGGCAACCAAACAGCCTTTTGATCTGCTTTCCAGCATTGGCAGCGACTGCGTGGGTGCGATCCAGCTTTACCCTGAACA
TGCAGATGTGGCCCCGGTAAAGCAAGTGAACGCCGTACCTGTCAGTGACGAAGAAATAGAGCAGCTTCTGCTGGGGTACC
GCGAGGCGCCGTTGGGCATGGTGGCGGGTACGGATGATTTCCGGATCTCTCTGGCGGGTGCGCAGGAAAAGACCGCTCTG
CTTTGGTTCGGCAATCAGTGGTGCCGGCCACAGGGGAGTACGCCAACCAGCCACATCATAAAACTGCCCATTGGGCATAT
CGCGCATAACAATCTGGATCTCAGCGAAAGCTGTGAGAACGAGTGGTTATGTTTACGCATTGCAGAACAGTTTGGCCTGC
CGGTAGCGCAGGCTGAGTTGGCGCGTTTTGGTGAACAAAAGGCTTTGATCGTTGAGCGTTTTGACCGGCGTTGGGCGCGG
GATAACAGTTGGTTGATTCGTTTGCCGCAAGAGGATTTCTGCCAGGCGTTAGGCATTGCTCCTGCGCTGAAATATGAGGC
TGATGGTGGGCCCGGTATTGCGGCTGCGATGCAACTGTTAATGGGTTCTCAGCAGCCATTACTCGATCGCGACACCTTCT
TTAAAAGCCAAATTGTATTCTGGATGCTGGCGGCCATTGATGGGCATGCCAAAAACTTTAGCCTGTTCATTGAGCAGGAA
ACGGCCTATCGAATGACCCCGCTTTATGATGTGCTCTCGGGTTACCCATTCATGCATGCCCGTGGCATTGCACCACAGAA
AGCCAAAATGGCCATGGCCGTGCTGGGGCAGAGCCGCCATTACCGTTGGAGCCAGATCTTGCCCAGGCACTTTATCTCTA
CCGCGAGAGCGGTGGGGTATTCCGAAGAGAAAACGCTGCAGGTGATGGCTGAGCTAAAAGCGCAAACAGAGCAGGCGATC
GCTAATGTGGAAGCAATGCTGCCGGACGAGTTTCCTCGTTCTGTGAGTGATGCGATTTTCTCTGGGGTTCGGCGGCAGGC
TGAGAGGTTGGTGGGGTAG

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16700.15 Da        Isoelectric Point: 5.7723

>AT151812 WP_004245528.1 NZ_CP049942:3172109-3172561 [Proteus mirabilis]
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY

Download         Length: 453 bp

>AT151812 NZ_CP065747:c5064575-5064327 [Serratia plymuthica]
ATGAAAATCACCTCGGCAAAGATGTTGGCGCATGCGCTACGCAATGAACGTAAAAAGCGTAACCAAAGCCAAAGTAAAAC
TGCTGACAGCATTGGGTTAAAGCAGGCCACGGTTTCCGCGTTTGAAAACAACCCGGACGGCACACGGCTGGAGACGTTAT
TCAAACTGCTTGCTGCGCTGGATTTAGAGCTACAAGTGACTCCGCGCGGTAAGCCAGTCGATCCCAAAACCTGGGATCAG
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4F2H3

References