Detailed information of TA system TA151811

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1784374..1785173
• Replicon: chromosome
• Accession: NZ_CP049942
• Organism: Proteus mirabilis strain XH1569

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A8E3RD10
• Locus tag: G9R00_RS08605
• Protein ID: WP_004247966.1
• Coordinates: 1784649..1785173 (+)
• Length: 175 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: B4EVS2
• Locus tag: G9R00_RS08600
• Protein ID: WP_004247964.1
• Coordinates: 1784374..1784652 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9R00_RS08575	1779724..1780806	+	1083	WP_004242680.1	peptide chain release factor 1	-
G9R00_RS08580	1780806..1781654	+	849	WP_004247962.1	peptide chain release factor N(5)-glutamine methyltransferase	-
G9R00_RS08585	1781632..1782447	+	816	WP_004242688.1	invasion regulator SirB1	-
G9R00_RS08590	1782505..1783359	+	855	WP_004242689.1	3-deoxy-8-phosphooctulonate synthase	-
G9R00_RS08595	1783367..1784296	+	930	WP_004242691.1	TIGR01212 family radical SAM protein	-
G9R00_RS08600	1784374..1784652	+	279	WP_004247964.1	DUF1778 domain-containing protein	Antitoxin
G9R00_RS08605	1784649..1785173	+	525	WP_004247966.1	hypothetical protein	Toxin
G9R00_RS08610	1785254..1786954	-	1701	WP_004247967.1	C4-dicarboxylic acid transporter DauA	-
G9R00_RS08620	1787916..1788857	+	942	WP_004242695.1	glyoxylate/hydroxypyruvate reductase GhrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (5-87)

Sequences

Toxin

Protein

• Length: 175 a.a.
• Molecular weight: 19192.12 Da
• Isoelectric Point: 9.3561

>T151811 WP_004247966.1 NZ_CP049942:1784649-1785173 [Proteus mirabilis]
MTIPNWHEEAISKKHNRNGFNCGDAVLNQFLYRHARQNHENGSAKTYLAINNSNNIILGYYSLCPASIEFERTPELIKHG
LARHDIPVFKLARLATDLSVQGKGLGGQLLLAAGRRCLSVASELGGVALLIDAKNERVANWYISYGAIPLLDTPLSLLIS
FKTIYTALSMANKI

Nucleotide

• Length: 525 bp

>T151811 NZ_CP065747:4672860-4673150 [Serratia plymuthica]
GTGCCACAACTGATATGGACGCCAGCGGCGCTGCTGGATGTACAGCAGCTTTATCGATTTCTGGCTGAGAAGGATCTCAA
TTCGGCAAAGCGCGCCGTCGCCACTATTCGTAACTGCATCAAAATAATAGCGCACCAACCCCATATTGGCCGCCCCGCTA
AAGATATGGCACCTGAATTCAGGGAGTGGCCTATCGATTTCGGCAATAGCGGTTATCTTGTTCTGTATCGGTTTAACGGT
GTAACCGCCGTTATTTTGGCTATTCGCCACCAAAGCGAAACCGGGTATTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10252.82 Da
• Isoelectric Point: 5.1369

>AT151811 WP_004247964.1 NZ_CP049942:1784374-1784652 [Proteus mirabilis]
MAQALVENSERVSIRITTEDKSLLVRAASLENTNLTEFVLRNIVPVARQVIENNERLKLSEKDTLRVMELLDNPPKPNAK
LLAAAFALPDNA

Nucleotide

• Length: 279 bp

>AT151811 NZ_CP065747:4672594-4672872 [Serratia plymuthica]
ATGGCTACTGCTACGTCGATAAAAATTGATGATGAGCTTAAACAACGGGTGCAACACATTGCCGCGGCCCATCAGCGCAG
CGCACACTGGATTATGCGTGAAGCCATTCGTGAATATGTCGAGCGTGAAGAAAAACGCGAGGCTGTTCGCAACGATGCAT
TACAGGCATGGGAAACCTATCAGGCCAATGGTAAACATTTGACTCAGGACGAGGCTGACGGCTGGCTCTCCGATCTGGAA
AAAGGTGATGATACGGAGATACCCGGGTGCCACAACTGA

Structures

Antitoxin

• AlphaFold DB: B4EVS2