Detailed information of TA system TA151810

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 13289..13890
• Replicon: chromosome
• Accession: NZ_CP049942
• Organism: Proteus mirabilis strain XH1569

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: G9R00_RS00060
• Protein ID: WP_049199790.1
• Coordinates: 13289..13672 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1Z1SPN9
• Locus tag: G9R00_RS00065
• Protein ID: WP_004246496.1
• Coordinates: 13669..13890 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9R00_RS00035	8353..9840	-	1488	WP_017826983.1	PLP-dependent aminotransferase family protein	-
G9R00_RS00040	9969..10427	+	459	WP_004249766.1	GNAT family N-acetyltransferase	-
G9R00_RS00045	10523..11260	-	738	WP_049199787.1	sel1 repeat family protein	-
G9R00_RS00050	11369..12268	+	900	WP_049199788.1	N-acetylmuramic acid 6-phosphate etherase	-
G9R00_RS00055	12568..12882	-	315	WP_004246498.1	helix-turn-helix domain-containing protein	-
G9R00_RS00060	13289..13672	-	384	WP_049199790.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
G9R00_RS00065	13669..13890	-	222	WP_004246496.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
G9R00_RS00070	14171..15034	-	864	WP_004249947.1	YicC family protein	-
G9R00_RS00075	15161..15877	+	717	WP_165708689.1	ribonuclease PH	-
G9R00_RS00080	15959..16603	+	645	WP_004246493.1	orotate phosphoribosyltransferase	-
G9R00_RS00085	16922..17527	-	606	WP_004246491.1	nucleoid occlusion factor SlmA	-
G9R00_RS00090	17647..18105	-	459	WP_004246490.1	dUTP diphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (5-115)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14490.58 Da
• Isoelectric Point: 9.4804

>T151810 WP_049199790.1 NZ_CP049942:c13672-13289 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGRIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Nucleotide

• Length: 384 bp

>T151810 NZ_CP065747:4430164-4430367 [Serratia plymuthica]
ATGACTAAAATTGACTATCTGATGCGTTTACGTAAATGCACCACGATTGACACCCTGGAACGCGTTATTGAAAAAAATAA
GTATGAGCTTTCGGATGACGAACTAGAGCTGTTCTACTCTGCAGCGGACCACCGTTTGGCCGAGCTCACCATGAATAAGC
TTTACGATAAAATCCCCGTTGCCGTTTGGAAATTCGTACGATAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8260.23 Da
• Isoelectric Point: 5.5667

>AT151810 WP_004246496.1 NZ_CP049942:c13890-13669 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Nucleotide

• Length: 222 bp

>AT151810 NZ_CP065747:4429745-4430113 [Serratia plymuthica]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
AACACTGGGCGACAGCCACCACGGCTGGGTGAACGATCCAACGTCTTCCGTCAACCTCCAGCTTAACGAGTTGATTGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAAAGTGATTTATCGGAGTTAGTCGAAGAGTATCTC
GACGATACCTACACGCTGTTTAGCAGTTATGGTATTAATGATTCCGATTTGCGCCGCTGGCAAAAAACCAAAGCGCGATT
ATTCAGAATGTTCTCAGGAGAGGGCATCTGTACGACAATGAAAACTTAG

Structures

Antitoxin

• AlphaFold DB: A0A1Z1SPN9