Detailed information of TA system TA151809

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4006584..4008155
• Replicon: chromosome
• Accession: NZ_CP049941
• Organism: Proteus mirabilis strain XH1568

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: B4F0T8
• Locus tag: G9Q98_RS18500
• Protein ID: WP_012368637.1
• Coordinates: 4006584..4007897 (-)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: G9Q98_RS18505
• Protein ID: WP_004249771.1
• Coordinates: 4007898..4008155 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9Q98_RS18480	4001753..4002556	+	804	WP_004249775.1	energy transducer TonB	-
G9Q98_RS18485	4002610..4004571	-	1962	WP_004249774.1	hypothetical protein	-
G9Q98_RS18490	4004603..4005532	-	930	WP_004246518.1	metallophosphoesterase	-
G9Q98_RS18495	4005717..4006181	-	465	WP_004249773.1	DUF1097 domain-containing protein	-
G9Q98_RS18500	4006584..4007897	-	1314	WP_012368637.1	type II toxin-antitoxin system HipA family toxin	Toxin
G9Q98_RS18505	4007898..4008155	-	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
G9Q98_RS18510	4008304..4009668	-	1365	WP_004246513.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
G9Q98_RS18515	4009806..4011446	-	1641	WP_004246512.1	membrane protein insertase YidC	-
G9Q98_RS18520	4011449..4011709	-	261	WP_012368639.1	membrane protein insertion efficiency factor YidD	-
G9Q98_RS18525	4011673..4012032	-	360	WP_004246510.1	ribonuclease P protein component	-
G9Q98_RS18530	4012050..4012193	-	144	WP_004246509.1	50S ribosomal protein L34	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49670.78 Da
• Isoelectric Point: 6.5023

>T151809 WP_012368637.1 NZ_CP049941:c4007897-4006584 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T151809 NZ_CP065747:c3909683-3909366 [Serratia plymuthica]
ATGCAATTTACGGTATACGCGAATACGGGGAAAAGCGCAGTCTATCCTCTGCTGCTTGATGTGACGAACGATATCATCGA
GCAATTAAATCGCCGAGTTATGATCCCGTTATTACCCATTGAAAAGTATCCGGCCAGTACTCGCCCGGAACGCTTGAACC
CTTTGGTCAGGCTGGTGGATGACAACGAGTACGCCGTTATGACTCATGAGATGGCAAGTATTCCCGTTCGTATCCTGGGC
GCTGAATTTTGCGATGCTTCCCAATACCGAACCAAGGTGAAAGCCGCAATAGATTTTCTTTTCGACGGTATCAGATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT151809 WP_004249771.1 NZ_CP049941:c4008155-4007898 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT151809 NZ_CP065747:c3909922-3909686 [Serratia plymuthica]
ATGCCAGTAAAACAACGAACGACCCAAAGCGTTACCATGGCGGTGGAACGCAGTTTACTGAGCCGTGCACGTGAGGCGGG
CATTAACCTCAGTACTACGCTGAATACTGCTTTGGATGCCGAATTGCGTCAGCATGAGATGAGGAAATGGAAGGAAGAAA
ACCGAGAAGCGATCGATGCTTTAAATCGTTTTCATGAAGAACATGGCTGTTTCAGTGACGAATACAGGACGTTTTAG

Structures

Toxin

• AlphaFold DB: B4F0T8

Antitoxin

• AlphaFold DB: B4F0T9