Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3719734..3720433 Replicon chromosome
Accession NZ_CP049941
Organism Proteus mirabilis strain XH1568

Toxin (Protein)


Gene name relE Uniprot ID B4EZ96
Locus tag G9Q98_RS17220 Protein ID WP_004249093.1
Coordinates 3719734..3720120 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag G9Q98_RS17225 Protein ID WP_004246828.1
Coordinates 3720113..3720433 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9Q98_RS17205 3715753..3716334 - 582 WP_012368524.1 DNA-3-methyladenine glycosylase I -
G9Q98_RS17210 3716585..3717490 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
G9Q98_RS17215 3717500..3719572 + 2073 WP_004246830.1 glycine--tRNA ligase subunit beta -
G9Q98_RS17220 3719734..3720120 + 387 WP_004249093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G9Q98_RS17225 3720113..3720433 + 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
G9Q98_RS17230 3720483..3720917 - 435 WP_004246827.1 hypothetical protein -
G9Q98_RS17235 3720910..3721794 - 885 WP_004249091.1 endonuclease/exonuclease/phosphatase family protein -
G9Q98_RS17240 3722012..3723298 - 1287 WP_074561560.1 DUF3748 domain-containing protein -
G9Q98_RS17245 3723435..3724052 + 618 WP_004246822.1 trimeric intracellular cation channel family protein -
G9Q98_RS17250 3724354..3724977 + 624 WP_004246821.1 guanylate kinase -
G9Q98_RS17255 3725032..3725307 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14294.64 Da        Isoelectric Point: 10.0642

>T151808 WP_004249093.1 NZ_CP049941:3719734-3720120 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Download         Length: 387 bp

>T151808 NZ_CP065747:c3490984-3490888 [Serratia plymuthica]
AACAAGCCCTGCACAAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT151808 WP_004246828.1 NZ_CP049941:3720113-3720433 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp

>AT151808 NZ_CP065747:3490886-3491028 [Serratia plymuthica]
ATAAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTTTGTGCAGGGCTTGTTCAGCCATGCACTTTAAGAGTAGCTTACCGCGCTAGTTTTGCCAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZ96

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References