Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 3234279..3236001 | Replicon | chromosome |
| Accession | NZ_CP049941 | ||
| Organism | Proteus mirabilis strain XH1568 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | B4EWT0 |
| Locus tag | G9Q98_RS15060 | Protein ID | WP_012368380.1 |
| Coordinates | 3234279..3235217 (-) | Length | 313 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | - |
| Locus tag | G9Q98_RS15065 | Protein ID | WP_041707152.1 |
| Coordinates | 3235210..3236001 (-) | Length | 264 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G9Q98_RS15040 | 3230220..3230732 | - | 513 | WP_175286101.1 | S26 family signal peptidase | - |
| G9Q98_RS15045 | 3230716..3231063 | - | 348 | WP_012368378.1 | hypothetical protein | - |
| G9Q98_RS15050 | 3231056..3233455 | - | 2400 | WP_012368379.1 | type IV secretion system protein TraC | - |
| G9Q98_RS15055 | 3233455..3234147 | - | 693 | WP_001228924.1 | DsbC family protein | - |
| G9Q98_RS15060 | 3234279..3235217 | - | 939 | WP_012368380.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| G9Q98_RS15065 | 3235210..3236001 | - | 792 | WP_041707152.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| G9Q98_RS15070 | 3236221..3236607 | - | 387 | WP_000180225.1 | hypothetical protein | - |
| G9Q98_RS15075 | 3236604..3237176 | - | 573 | WP_001944091.1 | type IV conjugative transfer system lipoprotein TraV | - |
| G9Q98_RS15080 | 3237251..3238540 | - | 1290 | WP_012368382.1 | TraB/VirB10 family protein | - |
| G9Q98_RS15085 | 3238543..3239439 | - | 897 | WP_041707153.1 | type-F conjugative transfer system secretin TraK | - |
| G9Q98_RS15090 | 3239423..3240049 | - | 627 | WP_000667170.1 | hypothetical protein | - |
| G9Q98_RS15095 | 3240046..3240327 | - | 282 | WP_000433891.1 | type IV conjugative transfer system protein TraL | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | tet(J) / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR | - | 3138400..3325876 | 187476 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 35534.79 Da Isoelectric Point: 4.9081
>T151807 WP_012368380.1 NZ_CP049941:c3235217-3234279 [Proteus mirabilis]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALVNVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALVNVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
Download Length: 939 bp
>T151807 NZ_CP065747:c2372006-2371824 [Serratia plymuthica]
GTGAAAAGTTCAGAACTGATCAGGCTGTTAGAACGAGAAGGTTGGGTTTTAGAGCGGATAAAGGGAAGCCACCATCAGTT
TAAACATCCGGGATCTCGTTTGGTGATCACCGTTCCACACCCGCGTAAAGATCTGAAGCCGGGAACGCTGCGCCAGATCA
TGAAAGATGCCGGGCTGTGCTAA
GTGAAAAGTTCAGAACTGATCAGGCTGTTAGAACGAGAAGGTTGGGTTTTAGAGCGGATAAAGGGAAGCCACCATCAGTT
TAAACATCCGGGATCTCGTTTGGTGATCACCGTTCCACACCCGCGTAAAGATCTGAAGCCGGGAACGCTGCGCCAGATCA
TGAAAGATGCCGGGCTGTGCTAA
Antitoxin
Download Length: 264 a.a. Molecular weight: 30116.50 Da Isoelectric Point: 9.3718
>AT151807 WP_041707152.1 NZ_CP049941:c3236001-3235210 [Proteus mirabilis]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLCSGVYYRPDARGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDGIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRVDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLCSGVYYRPDARGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDGIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRVDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
Download Length: 792 bp
>AT151807 NZ_CP065747:c2371794-2371381 [Serratia plymuthica]
ATGTTCTACCCTGCTTATGTACATTCAGACCTCGACGGCAGCGCCAGCGGTTTCTTCCCCGATGTGCCGGGCTGTTATTT
TGCCGGCGATACCCTCGATAAAGCCTTTGAAGATGCCAAAGGCGCGCTGGATGCGCATTTCGAACTTCTGAGCGAAGACA
ACCAGGCCATTCCGCGCCCACAGGCCGTTTCCTTCCATCTGGCACAGGAAAACGACACCCTGAACGGCGGGCAGTGGCTG
CTGGTCGATATCAATATGGATAAGTTCGATGGGCGGGCGGAACGTATCAATATCACCCTGCCGCACCGCTTGCTGAACCG
CATCGATTCACTGGTGCAGCAGCATCCTGGCTATGGGAGCCGCAGCGCCTTTTTGGCCGCCGCCGCCCGTAATGAATTAT
TGAAAGTCGGTTAG
ATGTTCTACCCTGCTTATGTACATTCAGACCTCGACGGCAGCGCCAGCGGTTTCTTCCCCGATGTGCCGGGCTGTTATTT
TGCCGGCGATACCCTCGATAAAGCCTTTGAAGATGCCAAAGGCGCGCTGGATGCGCATTTCGAACTTCTGAGCGAAGACA
ACCAGGCCATTCCGCGCCCACAGGCCGTTTCCTTCCATCTGGCACAGGAAAACGACACCCTGAACGGCGGGCAGTGGCTG
CTGGTCGATATCAATATGGATAAGTTCGATGGGCGGGCGGAACGTATCAATATCACCCTGCCGCACCGCTTGCTGAACCG
CATCGATTCACTGGTGCAGCAGCATCCTGGCTATGGGAGCCGCAGCGCCTTTTTGGCCGCCGCCGCCCGTAATGAATTAT
TGAAAGTCGGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|