Detailed information of TA system TA151807

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3234279..3236001
• Replicon: chromosome
• Accession: NZ_CP049941
• Organism: Proteus mirabilis strain XH1568

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: B4EWT0
• Locus tag: G9Q98_RS15060
• Protein ID: WP_012368380.1
• Coordinates: 3234279..3235217 (-)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: G9Q98_RS15065
• Protein ID: WP_041707152.1
• Coordinates: 3235210..3236001 (-)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9Q98_RS15040	3230220..3230732	-	513	WP_175286101.1	S26 family signal peptidase	-
G9Q98_RS15045	3230716..3231063	-	348	WP_012368378.1	hypothetical protein	-
G9Q98_RS15050	3231056..3233455	-	2400	WP_012368379.1	type IV secretion system protein TraC	-
G9Q98_RS15055	3233455..3234147	-	693	WP_001228924.1	DsbC family protein	-
G9Q98_RS15060	3234279..3235217	-	939	WP_012368380.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
G9Q98_RS15065	3235210..3236001	-	792	WP_041707152.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
G9Q98_RS15070	3236221..3236607	-	387	WP_000180225.1	hypothetical protein	-
G9Q98_RS15075	3236604..3237176	-	573	WP_001944091.1	type IV conjugative transfer system lipoprotein TraV	-
G9Q98_RS15080	3237251..3238540	-	1290	WP_012368382.1	TraB/VirB10 family protein	-
G9Q98_RS15085	3238543..3239439	-	897	WP_041707153.1	type-F conjugative transfer system secretin TraK	-
G9Q98_RS15090	3239423..3240049	-	627	WP_000667170.1	hypothetical protein	-
G9Q98_RS15095	3240046..3240327	-	282	WP_000433891.1	type IV conjugative transfer system protein TraL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(J) / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR	-	3138400..3325876	187476

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (99-250)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35534.79 Da
• Isoelectric Point: 4.9081

>T151807 WP_012368380.1 NZ_CP049941:c3235217-3234279 [Proteus mirabilis]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALVNVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Nucleotide

• Length: 939 bp

>T151807 NZ_CP065747:c2372006-2371824 [Serratia plymuthica]
GTGAAAAGTTCAGAACTGATCAGGCTGTTAGAACGAGAAGGTTGGGTTTTAGAGCGGATAAAGGGAAGCCACCATCAGTT
TAAACATCCGGGATCTCGTTTGGTGATCACCGTTCCACACCCGCGTAAAGATCTGAAGCCGGGAACGCTGCGCCAGATCA
TGAAAGATGCCGGGCTGTGCTAA

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 30116.50 Da
• Isoelectric Point: 9.3718

>AT151807 WP_041707152.1 NZ_CP049941:c3236001-3235210 [Proteus mirabilis]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLCSGVYYRPDARGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDGIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRVDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Nucleotide

• Length: 792 bp

>AT151807 NZ_CP065747:c2371794-2371381 [Serratia plymuthica]
ATGTTCTACCCTGCTTATGTACATTCAGACCTCGACGGCAGCGCCAGCGGTTTCTTCCCCGATGTGCCGGGCTGTTATTT
TGCCGGCGATACCCTCGATAAAGCCTTTGAAGATGCCAAAGGCGCGCTGGATGCGCATTTCGAACTTCTGAGCGAAGACA
ACCAGGCCATTCCGCGCCCACAGGCCGTTTCCTTCCATCTGGCACAGGAAAACGACACCCTGAACGGCGGGCAGTGGCTG
CTGGTCGATATCAATATGGATAAGTTCGATGGGCGGGCGGAACGTATCAATATCACCCTGCCGCACCGCTTGCTGAACCG
CATCGATTCACTGGTGCAGCAGCATCCTGGCTATGGGAGCCGCAGCGCCTTTTTGGCCGCCGCCGCCCGTAATGAATTAT
TGAAAGTCGGTTAG

Structures

Toxin

• AlphaFold DB: B4EWT0