Detailed information of TA system TA151806

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 3077616..3078637
• Replicon: chromosome
• Accession: NZ_CP049941
• Organism: Proteus mirabilis strain XH1568

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: A0A8E4FRK4
• Locus tag: G9Q98_RS14385
• Protein ID: WP_017827532.1
• Coordinates: 3078068..3078637 (+)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: B4F2H3
• Locus tag: G9Q98_RS14380
• Protein ID: WP_004245528.1
• Coordinates: 3077616..3078068 (+)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9Q98_RS14360	3073401..3073931	-	531	WP_004245524.1	RNA pyrophosphohydrolase	-
G9Q98_RS14365	3074201..3075214	+	1014	WP_004245525.1	thiamine ABC transporter substrate binding subunit	-
G9Q98_RS14370	3075214..3076794	+	1581	WP_004245526.1	thiamine/thiamine pyrophosphate ABC transporter permease ThiP	-
G9Q98_RS14375	3076787..3077488	+	702	WP_004245527.1	thiamine ABC transporter ATP-binding protein ThiQ	-
G9Q98_RS14380	3077616..3078068	+	453	WP_004245528.1	helix-turn-helix domain-containing protein	Antitoxin
G9Q98_RS14385	3078068..3078637	+	570	WP_017827532.1	PIN domain-containing protein	Toxin
G9Q98_RS14390	3078753..3081107	+	2355	WP_036895567.1	DNA polymerase II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-113)

Antitoxin

• SinI-like, DNA-binding domain (80-125)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 21601.08 Da
• Isoelectric Point: 7.0180

>T151806 WP_017827532.1 NZ_CP049941:3078068-3078637 [Proteus mirabilis]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLAAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKDPP
MTVETFLGCLQKQKLPQFISHLRAFQILL

Nucleotide

• Length: 570 bp

>T151806 NZ_CP065747:1433508-1433897 [Serratia plymuthica]
ATGTATATGTTTGACACCAATACCGTGAGCCACCTGTTTCGCCGGCACCCGGGTTTGCTGAGTGCGATGGAAAAGGTGCC
GCCTTCCACCGTATGCATTTCCAGCATCACGGAGGCAGAGCTGCTTTTTGGCGTGGCCAAGCGGCAGAGTAAAGCGTTGA
AAGCCATGGTAACGGCGTTTTTAGCCGCGGTGACCGTTTATGACTGGGATAGCGAAGCTGCCCGCTGTTATGGCGTGATG
CGGGCGAGCATGGAGAAAAAAGGCAAAGTCCTGGGCGCGCTGGACCAGTTGATTGCCGCGCATGCGCTTAGCCGGGGCGC
GACAATGGTCACTAGCGATCGGGCCTTCGGCATGGTGTCCGGGCTGGACGTTGAAGACTGGACCCTATAG

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16700.15 Da
• Isoelectric Point: 5.7723

>AT151806 WP_004245528.1 NZ_CP049941:3077616-3078068 [Proteus mirabilis]
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY

Nucleotide

• Length: 453 bp

>AT151806 NZ_CP065747:1433242-1433505 [Serratia plymuthica]
ATGGAAAGAATCGCAAAGCTGTTTAAAAATGGCAGAAATCAGGCGGTGAGGTTACCCGTGGAATTCGAATTTGACACAGA
TCGCGTATATATCCGCCGCGATCGGGAGGGGAATGTGATTTTATCGAAATACCCTGCAAAACCGGACAGTTGGGAGCCGC
TGTTGAACATAATCGCCAAAACGCCGGTGCCGCATGATTTTCTGGGCGCGGATGAACGCCAACAGGGCATTGCCGACCGG
GATCCTTTCGCAGAGGAAGAGTAA

Structures

Antitoxin

• AlphaFold DB: B4F2H3