Detailed information of TA system TA151805

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1487041..1487686
• Replicon: chromosome
• Accession: NZ_CP049941
• Organism: Proteus mirabilis strain XH1568

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: B4ET86
• Locus tag: G9Q98_RS07020
• Protein ID: WP_004247035.1
• Coordinates: 1487501..1487686 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B4ET85
• Locus tag: G9Q98_RS07015
• Protein ID: WP_004247034.1
• Coordinates: 1487041..1487454 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9Q98_RS06980	1482596..1482754	-	159	WP_165715135.1	hypothetical protein	-
G9Q98_RS06985	1483206..1483382	+	177	WP_004247793.1	hypothetical protein	-
G9Q98_RS06990	1483551..1484297	-	747	WP_141192022.1	class I SAM-dependent methyltransferase	-
G9Q98_RS07000	1485147..1485725	+	579	WP_004247030.1	alpha/beta hydrolase	-
G9Q98_RS07005	1485838..1486131	-	294	Protein_1334	LysE family transporter	-
G9Q98_RS07010	1486445..1486945	-	501	WP_041707083.1	response regulator	-
G9Q98_RS07015	1487041..1487454	-	414	WP_004247034.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
G9Q98_RS07020	1487501..1487686	-	186	WP_004247035.1	type II toxin-antitoxin system HicA family toxin	Toxin
G9Q98_RS07025	1487797..1488567	+	771	Protein_1338	DUF1073 domain-containing protein	-
G9Q98_RS07030	1489126..1489677	-	552	WP_017628396.1	PH domain-containing protein	-
G9Q98_RS07035	1489741..1490055	-	315	WP_017628395.1	hypothetical protein	-
G9Q98_RS07045	1490462..1492195	-	1734	WP_004247798.1	LPS biosynthesis-modulating metalloenzyme YejM	-
G9Q98_RS07050	1492219..1492446	-	228	WP_004247042.1	YejL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1481807..1499669	17862

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7049.30 Da
• Isoelectric Point: 10.9659

>T151805 WP_004247035.1 NZ_CP049941:c1487686-1487501 [Proteus mirabilis]
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN

Nucleotide

• Length: 186 bp

>T151805 NZ_CP065747:c1130455-1130111 [Serratia plymuthica]
ATGTGGCAAGTAGTAACCGTCGAACGATTCGACGACTGGTTTTTATCACTGAACGGCGATGAACAAAAAAGCCTGTTGGC
AGGAATATTCAAATTGCAGGAATTCGGCCCGCTGTTGGCTCGTCCGCATGCCGACACTTTGCATTTTTCCGGCTCAATAA
AGCATCTTAAAGAGCTGCGCATTCAGCACCGCGGCCGCCCGTTTCGGGTGTTTTTCGCCTTTGATCCGCAACGGCAAGCG
GTATTGCTATGCGGTGGTGATAAAACAGGCGATAAACGCTTTTACCAGCGCCTGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCAGAGGTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15251.98 Da
• Isoelectric Point: 4.3830

>AT151805 WP_004247034.1 NZ_CP049941:c1487454-1487041 [Proteus mirabilis]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI

Nucleotide

• Length: 414 bp

>AT151805 NZ_CP065747:c1130105-1129803 [Serratia plymuthica]
ATGGCCAAGCCTTTATCAAATTTGATCGATAAACTCGATCCCACCGTCGTTGCGGCAGCCCGGCAAAAGGCGGAGAAAGA
AATTTTTGAATTGCGGCTGGCGATGCTGCGGGAAGAACTTGCGGTATCTCAGGTAGAACTGGCGAAACGGCTTGGCATCA
GCCAGCCGTCGGTCGCTAATCTGGAAAAGCGCGGTAGCGAAATCAAACTCTCTTCACTGAAACGCTACATTGAAGCCATG
GGCGGCACGCTTTCGTTAGAGGTTGAGCTGCCCAACGGCCAGCATCGGCGGATGACACTCTGA

Structures

Toxin

• AlphaFold DB: B4ET86

Antitoxin

• AlphaFold DB: B4ET85