Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 13289..13890 Replicon chromosome
Accession NZ_CP049941
Organism Proteus mirabilis strain XH1568

Toxin (Protein)


Gene name doc Uniprot ID A0A2X2BIG8
Locus tag G9Q98_RS00060 Protein ID WP_004246497.1
Coordinates 13289..13672 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag G9Q98_RS00065 Protein ID WP_004246496.1
Coordinates 13669..13890 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9Q98_RS00035 8353..9840 - 1488 WP_036971864.1 PLP-dependent aminotransferase family protein -
G9Q98_RS00040 9969..10427 + 459 WP_036971866.1 GNAT family N-acetyltransferase -
G9Q98_RS00045 10523..11260 - 738 WP_004249950.1 sel1 repeat family protein -
G9Q98_RS00050 11369..12268 + 900 WP_004249949.1 N-acetylmuramic acid 6-phosphate etherase -
G9Q98_RS00055 12568..12882 - 315 WP_004246498.1 helix-turn-helix domain-containing protein -
G9Q98_RS00060 13289..13672 - 384 WP_004246497.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
G9Q98_RS00065 13669..13890 - 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
G9Q98_RS00070 14171..15034 - 864 WP_004249947.1 YicC family protein -
G9Q98_RS00075 15161..15877 + 717 WP_004249946.1 ribonuclease PH -
G9Q98_RS00080 15959..16603 + 645 WP_004246493.1 orotate phosphoribosyltransferase -
G9Q98_RS00085 16922..17527 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -
G9Q98_RS00090 17647..18105 - 459 WP_004246490.1 dUTP diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-115)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14471.53 Da        Isoelectric Point: 8.5125

>T151804 WP_004246497.1 NZ_CP049941:c13672-13289 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T151804 NZ_CP065747:1058484-1058906 [Serratia plymuthica]
GTGGCCCAGTGGCGATGTAATGTCCGCATTTCCTGGCGCACCCAGTTACTTTCGCTGCTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTACGGCCCGATCTGGCTGGTGTTGTTGACGCTGGTGGTATTTGAATGCA
TCCGCAGCCAAAAGCGCATTGCGTCGCGGCAGGGCGAACTGCGTCTGCTGGCGAATAAGCGGTTAAGTTGGCACGGACAG
GAATGGTTGCTGGCAAAGCAACCCTGGATGCCGCGTTACGGCATTTTGCTGACGCTGCAGCCGACGCAGGGCAAAAAACG
CCGCCGGCTGTGGCTGGCCTCCGACAGCATGGGCAAAGCCGAATGGCGGCATCTGCGCCAGTTGCTGCTGCACCCGTCGG
CCGATGATGACGAGGAACCCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT151804 WP_004246496.1 NZ_CP049941:c13890-13669 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT151804 NZ_CP065747:1058237-1058503 [Serratia plymuthica]
ATGGATATTAATAATAAAGCACGTATTCACTGGGCCTGCCGCCGTGGCATGCGTGAGCTGGACATCTCAATCATGCCGTT
CTTCGAGCATGAGTACGACCAGTTGAATGACGCAGACAAAGCGTTGTTTATCCGCCTGCTTGAGAGCGACGATCCCGATC
TGTTCAACTGGTTGATGAATCATGGCGCTCCGCAAGACAGTGAACTGCAGAGAATGGTGACACTGATCCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X2BIG8

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References