Detailed information of TA system TA151803

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 251796..252408
• Replicon: chromosome
• Accession: NZ_CP049938
• Organism: Streptococcus agalactiae strain ZQ0910

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A8G2N8L3
• Locus tag: G9U50_RS01435
• Protein ID: WP_000384860.1
• Coordinates: 251796..252131 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: G9U50_RS01440
• Protein ID: WP_000259017.1
• Coordinates: 252121..252408 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9U50_RS01410	246994..247635	+	642	WP_000591144.1	hypothetical protein	-
G9U50_RS01415	247935..248810	+	876	WP_000421240.1	hypothetical protein	-
G9U50_RS01420	248846..249280	+	435	WP_001220479.1	hypothetical protein	-
G9U50_RS01425	249597..250853	+	1257	WP_000122836.1	plasmid recombination protein	-
G9U50_RS01430	251021..251491	+	471	WP_000130119.1	hypothetical protein	-
G9U50_RS01435	251796..252131	-	336	WP_000384860.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G9U50_RS01440	252121..252408	-	288	WP_000259017.1	hypothetical protein	Antitoxin
G9U50_RS01445	252915..253205	+	291	WP_000078283.1	WXG100 family type VII secretion target	-
G9U50_RS01450	253307..253714	+	408	WP_000749954.1	hypothetical protein	-
G9U50_RS01455	253714..254274	+	561	WP_001865562.1	hypothetical protein	-
G9U50_RS01460	254247..254927	+	681	WP_001865565.1	hypothetical protein	-
G9U50_RS01465	254912..255298	+	387	WP_000259069.1	hypothetical protein	-
G9U50_RS01470	255332..255613	+	282	WP_000052407.1	hypothetical protein	-
G9U50_RS01475	256456..257316	+	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	243827..252682	8855

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13227.87 Da
• Isoelectric Point: 4.5348

>T151803 WP_000384860.1 NZ_CP049938:c252131-251796 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENSVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T151803 NZ_CP065747:c427721-427443 [Serratia plymuthica]
GTGACACTCAAGCGGACGGAACCCGCGATTGCCGATCGTATGGCAATTTATGACTACCTGGAAACAAAGAATCCGGCCGC
AGCGATAGAAATTGATAGCTTGATTTCAGCAGCTGCGACACGACTCTCACAAAACCCGTCCAGTGGAAAACCAGGCCAAG
TACCCGGTACACGTGAAATGGTTATTCATCATTCCTATTTTCTGGTTTATGAATTAATCAACGGGTTAATCATTATGCTG
GCCGTAGTGCATGCCCGCCGTCAGTGGCCCGCCAATTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT151803 WP_000259017.1 NZ_CP049938:c252408-252121 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT151803 NZ_CP065747:c428008-427739 [Serratia plymuthica]
ATGTCTGAATCTACCGTGGTTATCCGAGTGGATGAGGAATTAAAAATCGCCTTTGCCAGCGCAGCCAAAGCAGCCGATCG
CACCGCATCTCAGTTGTTGCGCGATTTCATGCGTGATTTTGTCAGTCGGCAAACTCATCAGAAAGAGTATGAGCAGTGGC
TACAGGAAAAAGTGGACTTAAGCCGTAAAGCGCTTAATGAAGGAAAAATCACTGATAATGAAGCCGTTGAGGCCTACTTC
GCTGAGCGCAGGTCAAAACTGACAAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6