Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2310098..2310693 Replicon chromosome
Accession NZ_CP049936
Organism Escherichia coli strain JL05

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag G9V97_RS10900 Protein ID WP_000239579.1
Coordinates 2310098..2310448 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag G9V97_RS10905 Protein ID WP_001223208.1
Coordinates 2310442..2310693 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9V97_RS10880 2305374..2306396 - 1023 WP_001296689.1 ABC transporter permease -
G9V97_RS10885 2306410..2307912 - 1503 WP_000205791.1 sugar ABC transporter ATP-binding protein -
G9V97_RS10890 2308222..2309178 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
G9V97_RS10895 2309488..2310018 + 531 WP_000055072.1 inorganic diphosphatase -
G9V97_RS10900 2310098..2310448 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
G9V97_RS10905 2310442..2310693 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
G9V97_RS10910 2310905..2311246 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
G9V97_RS10915 2311249..2315019 - 3771 WP_165746329.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T151794 WP_000239579.1 NZ_CP049936:c2310448-2310098 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T151794 NZ_CP065728:c1749358-1749137 [Moraxella nonliquefaciens]
TTGCTTTGTCCTTATTCCGATACTTTATATGACTCAAAATTTAACAACATGAAAGAATTGCGTATCCAAATCGGGGGTGA
CCCTTATCGTGCTTTTTATACGTTTGACCCCATACGACAAGCGATTGTGCTATGTGCAGGCAACAAAGTGGGCAATGAAA
AGCAGTTTTATAAACAGATGATACCGCTTGCTGATGAGTTTACATCAGCAGCATTTGGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT151794 WP_001223208.1 NZ_CP049936:c2310693-2310442 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT151794 NZ_CP065728:c1749115-1748816 [Moraxella nonliquefaciens]
ATGGCAAATCTTAATGATATGCTCGCCAAATCACCAAAAGAGCGTTTGGCTCGTGTGCAAAAAATGGCAGATGAGATGAT
TTTGGATTACAAGCTTTATCAGTTGCGTGAAGAGTTGGAGCTGTCGCAAAAACAGCTTGCCGAAGCCATGGGCATTACCC
AGCCGACCTTATCCGCCATTGAGAACCGCGGGGCAGAGATTAAGCTGTCTACACTAAAATGCTATGTAGAGACCATGGGT
GGAAAATTACGCATTGATGTGGAATTACCAACAGGTAAGCACGTTGGGTTTAATATTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References