151791

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 1599175..1600012 Replicon chromosome
Accession NZ_CP049936
Organism Escherichia coli strain JL05

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag G9V97_RS07695 Protein ID WP_000227784.1
Coordinates 1599470..1600012 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag G9V97_RS07690 Protein ID WP_001297137.1
Coordinates 1599175..1599486 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9V97_RS07665 1594195..1595142 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
G9V97_RS07670 1595164..1597155 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
G9V97_RS07675 1597145..1597759 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
G9V97_RS07680 1597759..1598088 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
G9V97_RS07685 1598100..1598990 + 891 WP_000971336.1 heme o synthase -
G9V97_RS07690 1599175..1599486 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
G9V97_RS07695 1599470..1600012 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
G9V97_RS07700 1600068..1601003 - 936 WP_001297127.1 sel1 repeat family protein -
G9V97_RS07705 1601410..1602774 + 1365 WP_001000978.1 MFS transporter -
G9V97_RS07710 1602902..1603393 - 492 WP_001138904.1 nucleotide binding protein YajQ -
G9V97_RS07715 1603561..1604472 + 912 WP_000705847.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T151791 WP_000227784.1 NZ_CP049936:1599470-1600012 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

>T151791 NZ_CP065725:c1276184-1275906 [Oligella ureolytica]
ATGATTAAATCATTTAAACATAAAGGCCTTAGAAAGTATTTTGAAACTGGAAATACTTCAGGTATTCAACCAAAACATGC
AGTTAGGTTACGTACCCAGCTTTCAGTATTAGATACGATTAAAAGCCCTGATGAAATTAATATAGTTAGTTGGAGATTGC
ATGCTTTGACTGGTAATTTAAAAGGCTACTGGTCTATAACTGTTAATGCAAATTGGCGTATCACTTTCAGATTTGAAGGT
GAAAATGTTTATGAAGTTGATTACTTAGATTATCACTAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT151791 WP_001297137.1 NZ_CP049936:1599175-1599486 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT151791 NZ_CP065725:c1275895-1275617 [Oligella ureolytica]
ATGAGAATGTACAATCCACCTCACCCAGGTCTTGTTATTAGAGAGTATTTAAATGATGTTACTGTTTCAGATGCAGCAAA
ACATTTAGGCATTACTAGGACTTCTTTATCAAGAATACTCAATGGCAAAACAGGTATATCACCTTTAATGGCTATTAAAC
TTGAAAAAGCATTTGGGGGAATAACAGCTGAGTCTTGGTTAGCGATGCAAGCAAAATATGACTTATGGCAAGAAGAGCAA
AGTTACGATGATACAGTTATACCATTTGAATTTGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References