Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1565101..1565719 Replicon chromosome
Accession NZ_CP049936
Organism Escherichia coli strain JL05

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag G9V97_RS07525 Protein ID WP_001291435.1
Coordinates 1565501..1565719 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag G9V97_RS07520 Protein ID WP_000344800.1
Coordinates 1565101..1565475 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9V97_RS07510 1560190..1561383 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G9V97_RS07515 1561406..1564555 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
G9V97_RS07520 1565101..1565475 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
G9V97_RS07525 1565501..1565719 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
G9V97_RS07530 1565891..1566442 + 552 WP_000102568.1 maltose O-acetyltransferase -
G9V97_RS07535 1566558..1567027 + 470 Protein_1472 YlaC family protein -
G9V97_RS07540 1567191..1568741 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
G9V97_RS07545 1568783..1569136 - 354 WP_000878140.1 DUF1428 domain-containing protein -
G9V97_RS07555 1569515..1569826 + 312 WP_000409911.1 MGMT family protein -
G9V97_RS07560 1569857..1570429 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T151790 WP_001291435.1 NZ_CP049936:1565501-1565719 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T151790 NZ_CP065725:c1275306-1275109 [Oligella ureolytica]
TTGACTTATAAAATACTTTATTCAGATAAAGCAAAAAAAGCGCTTTTAAAACTTGATAAACCAGTCGCTAAACGTATTCA
TCGGTTTTTAACTGAAAGAGTCTCCCAAGACCCAAAGAATCAAGGCGGTTTTCTTCAAGGAAATTTTTGGCGGCGTGAGT
TTATAAAAGAGTTTAATTTATCTGTTTTCATAATTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT151790 WP_000344800.1 NZ_CP049936:1565101-1565475 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT151790 NZ_CP065725:c1275514-1275296 [Oligella ureolytica]
ATGTTAGCAATACGATTACCTGACGAAATAGATAACCGCTTGAAAGATTTGGCGGAAAAGACGGGGCGTACAAAGTCTTT
TTACGCAAGAGAAGCAATCTTAAAACACTTAGATGATTTAGAAGGTATCTATCTTGCTGAAAGGGAGTTAGAACTGATTA
AGGCTGGCAAGTCTAAAACTTACTCAGCTGAAGAGGTAGGGAAAGAGCTTGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References