Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1480461..1481173 Replicon chromosome
Accession NZ_CP049934
Organism Leucobacter insecticola strain HDW9B

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G7067_RS06770 Protein ID WP_166322971.1
Coordinates 1480730..1481173 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G7067_RS06765 Protein ID WP_166322969.1
Coordinates 1480461..1480733 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7067_RS06740 1476724..1477641 + 918 WP_166322959.1 phosphate/phosphite/phosphonate ABC transporter substrate-binding protein -
G7067_RS06745 1477672..1478547 + 876 WP_166322961.1 phosphonate ABC transporter ATP-binding protein -
G7067_RS06750 1478547..1479350 + 804 WP_166322963.1 phosphonate ABC transporter, permease protein PhnE -
G7067_RS06755 1479347..1480108 + 762 WP_166322965.1 tyrosine-protein phosphatase -
G7067_RS06760 1480206..1480406 - 201 WP_166322967.1 hypothetical protein -
G7067_RS06765 1480461..1480733 + 273 WP_166322969.1 antitoxin Antitoxin
G7067_RS06770 1480730..1481173 + 444 WP_166322971.1 PIN domain-containing protein Toxin
G7067_RS06775 1481170..1482006 - 837 WP_166322973.1 HpcH/HpaI aldolase/citrate lyase family protein -
G7067_RS06780 1481991..1482776 - 786 WP_166322975.1 fumarylacetoacetate hydrolase family protein -
G7067_RS06785 1482848..1483447 - 600 WP_166322977.1 TetR/AcrR family transcriptional regulator -
G7067_RS06790 1483467..1485005 - 1539 WP_205881084.1 hypothetical protein -
G7067_RS06795 1485199..1486167 + 969 WP_166322979.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1461125..1548477 87352


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-133)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16386.83 Da        Isoelectric Point: 6.7562

>T151776 WP_166322971.1 NZ_CP049934:1480730-1481173 [Leucobacter insecticola]
VIVLDVNVLVAAFRADHSHHGVARPWLMRLLETESAVIVPDLVWIGFLRVVTNRRIFDGPASPREALTFMEALTRSSAYR
RAPGLPDGHDVLHRTVEVTDARANLIPDAYIAAVALAFACPVATFDRDFHRFEGLRIVRPEVYGSET

Download         Length: 444 bp

>T151776 NZ_CP065711:2010870-2011139 [Staphylococcus carnosus]
ATGAGTAAATTAAATATTTCATTTTCTCCTGAAGCATTTGAAGATTATAAAAATTGGCAAACTCAAGATAAAAAAGTTTG
GAAGAAAATCAATCAATTGATTAAAAGTATTGATCGTGATGGCATGTTAGATGGAATTGGTAAGCCAGAACGTTTAAAAG
GTGGTTTCAGTGGTTGGTATAGCAGACGTATCACACAAGATCACAGATTAGTATATAAAGTAACAAGTGAATCAATTTTA
GCTGCTTCATGCAAGTATCATTATCAATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9637.67 Da        Isoelectric Point: 4.2904

>AT151776 WP_166322969.1 NZ_CP049934:1480461-1480733 [Leucobacter insecticola]
MRTTLRIEAPLLEAAKRNAARRQETLGEYVEEALRVYIAAQGSPAEVVDLPVFHGGGVKSGIDATSNRDLYDVLDEADAV
DGLDAHEAAS

Download         Length: 273 bp

>AT151776 NZ_CP065711:2010629-2010877 [Staphylococcus carnosus]
ATGGCTGTTGAAACATACTCAAATGCTAGAAAAAACTTTAGAAGTTTAATTAAACAAGTAAATGAAAACAGTGAAGCTAT
TACCATCACAACAAATGAAGAAAACGCCGTTTTAATGTCTGAAACTGATTATAATGCAATAATGGAGACTCTTTACTTAC
AACAAAACCCAGCTAACGCTGCACATCTCAAACGTTCAATTGAACAACTAGAAAAAGGCGATTCTGTTCAGGTAGAAATA
GATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References