Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1122675..1123239 Replicon chromosome
Accession NZ_CP049934
Organism Leucobacter insecticola strain HDW9B

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G7067_RS05105 Protein ID WP_166322472.1
Coordinates 1122675..1123022 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G7067_RS05110 Protein ID WP_166322474.1
Coordinates 1123009..1123239 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7067_RS05080 1118487..1118972 - 486 WP_166322466.1 transcription elongation factor GreA -
G7067_RS05085 1119140..1119595 - 456 WP_166322468.1 DUF4307 domain-containing protein -
G7067_RS05090 1119681..1120553 + 873 WP_205881207.1 mycothiol conjugate amidase Mca -
G7067_RS05095 1120550..1120822 + 273 WP_166322470.1 hypothetical protein -
G7067_RS05100 1120828..1122686 + 1859 Protein_1002 DNA helicase RecQ -
G7067_RS05105 1122675..1123022 - 348 WP_166322472.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G7067_RS05110 1123009..1123239 - 231 WP_166322474.1 ribbon-helix-helix domain-containing protein Antitoxin
G7067_RS05115 1123287..1124045 - 759 WP_166322476.1 hemolysin III family protein -
G7067_RS05120 1124157..1124942 + 786 WP_166322478.1 isoprenyl transferase -
G7067_RS05125 1124967..1126310 + 1344 WP_166322480.1 amidohydrolase -
G7067_RS05130 1126458..1126949 - 492 WP_166322482.1 S-ribosylhomocysteine lyase -
G7067_RS05135 1127024..1127377 - 354 WP_205881208.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12644.51 Da        Isoelectric Point: 7.4066

>T151775 WP_166322472.1 NZ_CP049934:c1123022-1122675 [Leucobacter insecticola]
MQRGEIRFVNFEPALGSEANKRRPAVIVSNDHANLVAERLGRGVLTVVPITSNAARVFPFHVLLSAEDTGLDRDSKAQAE
QLRSLSIDRIGEVIGHVPIAKMREVDEAIRLHLGL

Download         Length: 348 bp

>T151775 NZ_CP065711:2010629-2010877 [Staphylococcus carnosus]
ATGGCTGTTGAAACATACTCAAATGCTAGAAAAAACTTTAGAAGTTTAATTAAACAAGTAAATGAAAACAGTGAAGCTAT
TACCATCACAACAAATGAAGAAAACGCCGTTTTAATGTCTGAAACTGATTATAATGCAATAATGGAGACTCTTTACTTAC
AACAAAACCCAGCTAACGCTGCACATCTCAAACGTTCAATTGAACAACTAGAAAAAGGCGATTCTGTTCAGGTAGAAATA
GATGAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8402.31 Da        Isoelectric Point: 4.3455

>AT151775 WP_166322474.1 NZ_CP049934:c1123239-1123009 [Leucobacter insecticola]
MKISVSLKQEELATLDRFVAETGLPSRSAGLQHAIRLLNGPKLELAYATAWNEWSNSEENDLWDQSVSDGLSDAAR

Download         Length: 231 bp

>AT151775 NZ_CP065711:2010870-2011139 [Staphylococcus carnosus]
ATGAGTAAATTAAATATTTCATTTTCTCCTGAAGCATTTGAAGATTATAAAAATTGGCAAACTCAAGATAAAAAAGTTTG
GAAGAAAATCAATCAATTGATTAAAAGTATTGATCGTGATGGCATGTTAGATGGAATTGGTAAGCCAGAACGTTTAAAAG
GTGGTTTCAGTGGTTGGTATAGCAGACGTATCACACAAGATCACAGATTAGTATATAAAGTAACAAGTGAATCAATTTTA
GCTGCTTCATGCAAGTATCATTATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References