Detailed information of TA system TA151765

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1368672..1369333
• Replicon: chromosome
• Accession: NZ_CP049918
• Organism: Bordetella bronchiseptica strain KVNON-570

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: G6545_RS06285
• Protein ID: WP_003812073.1
• Coordinates: 1368672..1369097 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6545_RS06290
• Protein ID: WP_003812071.1
• Coordinates: 1369094..1369333 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6545_RS06265	1364486..1365463	+	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-
G6545_RS06270	1365484..1365996	-	513	WP_003812080.1	hypothetical protein	-
G6545_RS06275	1366495..1368000	+	1506	WP_003812078.1	tripartite tricarboxylate transporter permease	-
G6545_RS06280	1368098..1368562	-	465	WP_003812075.1	MarR family transcriptional regulator	-
G6545_RS06285	1368672..1369097	-	426	WP_003812073.1	PIN domain-containing protein	Toxin
G6545_RS06290	1369094..1369333	-	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
G6545_RS06295	1369407..1370249	-	843	WP_003812068.1	AraC family transcriptional regulator	-
G6545_RS06300	1370387..1370932	+	546	WP_003812065.1	peroxidase-related enzyme	-
G6545_RS06305	1370991..1371503	+	513	WP_003812062.1	redoxin domain-containing protein	-
G6545_RS06310	1371584..1371817	+	234	WP_033447224.1	DUF2945 domain-containing protein	-
G6545_RS06315	1371814..1372374	+	561	WP_003812059.1	DUF488 domain-containing protein	-
G6545_RS06320	1372452..1373498	+	1047	WP_003812057.1	Dyp-type peroxidase	-
G6545_RS06325	1373495..1374298	+	804	WP_003812055.1	bacteriocin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T151765 WP_003812073.1 NZ_CP049918:c1369097-1368672 [Bordetella bronchiseptica]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T151765 NZ_CP065700:3405138-3405452 [Atlantibacter hermannii]
ATGAAAACTTTACCTGCAACAACTCCGCAGGCAGCGAAGCTATGTCTGCCGCCCGTGGCTGTTTGGCAAATGTTACTGGC
ACGCCTGCTGGAACAGCACTATGGCCTGACACTGAACGATACATCGTTCAGTGATGAAACTGTTATTCAGGAACATATTG
ATGCCGGGATTACCCTGGCCGATGCAGTCAACTTTCTGGTGGATAAGTACGAACTGGTTCGCATTGATCGCAGAGGGTTG
AGTTGGCAGGCGCAATCATCCTATCTTCGGGCTGTAGATATCCTACGAGCTCGACAGGCAACTGGGTTGTTGTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT151765 WP_003812071.1 NZ_CP049918:c1369333-1369094 [Bordetella bronchiseptica]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT151765 NZ_CP065700:3404800-3405117 [Atlantibacter hermannii]
ATGAGCAACATCACATGGGGCCTGCAGCGGGATATTACGCCACGCCTGGGAGCTCGCCTTGTGCAGGAGGGGAACCGGCT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGTAAATTCAGTGACGCCGAATGCCAGAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATCGAGTCGATGCTGACCACCTATGAACTGAATCCCCGCCATGCCCACTGCGTCATCCTGTATCAC
AATGGTTTCACCTGCGAAGCCGATACTCTTGGCAGTTGCGGCTACGTATACGTCGCCGTTTATCCCACTCAGCGCTAA

Structures

Toxin

• AlphaFold DB: Q7WAH5