Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpA-brnA/BrnT_toxin-BrnA
Location 1071183..1071714 Replicon chromosome
Accession NZ_CP049918
Organism Bordetella bronchiseptica strain KVNON-570

Toxin (Protein)


Gene name shpA Uniprot ID A0A0C6P1L1
Locus tag G6545_RS04925 Protein ID WP_015064047.1
Coordinates 1071448..1071714 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID K0MF02
Locus tag G6545_RS04920 Protein ID WP_003816743.1
Coordinates 1071183..1071461 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6545_RS04895 1066613..1067707 + 1095 WP_003812637.1 TRAP transporter substrate-binding protein -
G6545_RS04900 1067919..1068548 + 630 WP_003812635.1 TRAP transporter small permease subunit -
G6545_RS04905 1068551..1070218 + 1668 WP_003812634.1 TRAP transporter large permease subunit -
G6545_RS04910 1070233..1070889 + 657 WP_003812630.1 phosphoribosylanthranilate isomerase -
G6545_RS04920 1071183..1071461 - 279 WP_003816743.1 BrnA antitoxin family protein Antitoxin
G6545_RS04925 1071448..1071714 - 267 WP_015064047.1 BrnT family toxin Toxin
G6545_RS04930 1071945..1073486 - 1542 WP_003812624.1 M81 family metallopeptidase -
G6545_RS04935 1073548..1074426 - 879 WP_003812621.1 tripartite tricarboxylate transporter substrate binding protein -
G6545_RS04940 1074823..1075455 + 633 WP_003812619.1 PAS domain-containing protein -
G6545_RS04945 1075566..1076276 + 711 WP_003812617.1 aquaporin Z -
G6545_RS04950 1076315..1076587 - 273 WP_003812615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(12-86)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10090.52 Da        Isoelectric Point: 9.4798

>T151764 WP_015064047.1 NZ_CP049918:c1071714-1071448 [Bordetella bronchiseptica]
MDITYDPAKNDKNIADRGLSFELVRGFEWASALVVEDTRQVYAETRYQALGKIDGRLHMVVFTVRGESLRIISLRKANAR
EVARYEKA

Download         Length: 267 bp

>T151764 NZ_CP065700:3189111-3189329 [Atlantibacter hermannii]
ATGTCAGAAAAACCCTTAACGAAAACTGATTATTTAATGCGTCTACGACGCTGCCAGACTATTGATACGCTTGAAAGAGT
CATTGAAAAAAATAAATACGAATTATCGGATAACGAATTGGCGGTATTTTATTCAGCGGCCGATCACCGTCTTGCCGAGC
TCACAATGAATAAGCTTTACGATAAAATACCATCGTCTGTGTGGAAATTTATTCGTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10412.89 Da        Isoelectric Point: 10.5548

>AT151764 WP_003816743.1 NZ_CP049918:c1071461-1071183 [Bordetella bronchiseptica]
MKKPDPEKIDRDNPEWTDAEFRRAKPAAEVLPESVHAMLGIRRRGPQKTPTKQVVTIRLSPDVVEAFKASGTGWQTRVDA
ALRDWLKTHQPG

Download         Length: 279 bp

>AT151764 NZ_CP065700:3188708-3189082 [Atlantibacter hermannii]
ATGGACGAATACTCACCAAAACGGCATGATATAGCCCAGCTAAAATTCCTGTGTGAAAATCTCTATCATGACTGCCTGCT
AACCCTTGGTGACAGCAATCATGGTTGGGTGAACGATCCAACCTCGGCCATCAACCTGCAGTTAAATGAATTGATTGAGC
ATATTGCGAGTTTTGCGCTTAATTATAAAATTAAGCATGACGAAGATAATGCATTGATCGAACACGTTGATGAGTATCTT
GATGATACCTTCATGCTGTTCAGCAACTATGGTATTAGCGCTCAGGATTTACAGAAATGGCGCAAATCAGGAAACCGTTT
GTTTCGATGTTTCGTCAACGTCAGTAAGGCCAACCCAGTGAGCCTATCTTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C6P1L1

Antitoxin

Source ID Structure
AlphaFold DB K0MF02

References