Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1623884..1624520 Replicon chromosome
Accession NZ_CP049916
Organism Acinetobacter lanii strain 185

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag G8D99_RS07600 Protein ID WP_166324038.1
Coordinates 1623884..1624066 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag G8D99_RS07605 Protein ID WP_166324042.1
Coordinates 1624116..1624520 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G8D99_RS07570 1619590..1619913 - 324 WP_166324026.1 TusE/DsrC/DsvC family sulfur relay protein -
G8D99_RS07575 1619959..1620243 - 285 WP_166324028.1 hypothetical protein -
G8D99_RS07580 1620271..1620621 - 351 WP_166324030.1 hypothetical protein -
G8D99_RS07585 1620665..1621033 - 369 WP_166324032.1 sulfurtransferase complex subunit TusD -
G8D99_RS07590 1621106..1622110 + 1005 WP_166324034.1 UDP-glucose 4-epimerase GalE -
G8D99_RS07595 1622320..1623714 + 1395 WP_166324036.1 class II fumarate hydratase -
G8D99_RS07600 1623884..1624066 + 183 WP_166324038.1 type II toxin-antitoxin system HicA family toxin Toxin
G8D99_RS07605 1624116..1624520 + 405 WP_166324042.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
G8D99_RS07610 1624798..1625289 + 492 WP_166324045.1 hypothetical protein -
G8D99_RS07615 1625637..1626239 + 603 WP_166324049.1 nitroreductase family protein -
G8D99_RS07620 1626402..1627634 - 1233 WP_166324052.1 MFS transporter -
G8D99_RS07625 1627627..1628094 - 468 WP_166324055.1 MarR family transcriptional regulator -
G8D99_RS07630 1628244..1629086 - 843 WP_166324057.1 DUF805 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1620404..1663173 42769


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6811.05 Da        Isoelectric Point: 10.5519

>T151763 WP_166324038.1 NZ_CP049916:1623884-1624066 [Acinetobacter lanii]
MKSLDLIRMIEADGWYQVRCKGDHHHFKHPTKKGLVTIPHPKKDLPPGTVNSILKQAGLK

Download         Length: 183 bp

>T151763 NZ_CP065700:c2749322-2748969 [Atlantibacter hermannii]
ATGACATGGACGGTTGTATTAACACCGGAGTTTGAGCAGTGGTTTGATAAACAAGAGGCAGGGCTGCAGGATCGCATCAA
CATGATGATCACCCTGTTAGAAATTAGCGGGCCCAACCTTGGACGCCCCCACGTTGACACACTCGTTGGATCGCGTTACC
CAAATATGAAAGAGCTACGTATACAATATGCCGGTGAGCCATGGCGCGTAGGGTTTGCCTTTAATCACAGACAGCAAGCT
GTACTGTTATATGGCGGCCAAAAAACGGGAAAAAAGCGCTTTTATACATTGTTAATTGCACAAGTCGATGCGATTTTCGC
ACGCGATCTCGCCCGTAAAAAGGAGACTCTATGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14806.69 Da        Isoelectric Point: 4.3170

>AT151763 WP_166324042.1 NZ_CP049916:1624116-1624520 [Acinetobacter lanii]
MLYPLAVERGSDQQAYGVIVPDIQGCFSAGDTFEEALENAKEAIAGHLEILAEDGEEIPLASEAVNFFDNDDYKGMVWAV
VDIDVSRYLGKAEKVNVTLPSRLIHLIDDRVKKDNRFKSRSAFLAASAERMLNA

Download         Length: 405 bp

>AT151763 NZ_CP065700:c2748972-2748676 [Atlantibacter hermannii]
ATGAAGACATTTCAGGAAAAACTAGCGGAATATTCACCCGAGCGCAGGGCGAAAATCGAGCGCATGGCGGAGGCATTCGC
TGCGGAAAATGGTCTGCCGACCCTTCGGGAAATGCGCGCGATGTCGCAGCAGGAACTCGCTGAACGACTGGGCGTGACCC
AGCCTGCGGTAGCCGCCATGGAGCGACGGGGAGAAGATATCAAAGTCTCGACGCTGAAACGCTATGCAGAAGCGTTAGGC
GGGGAGTTGAAAATCACCATTGAACTGCCCGAGGGGCGTAAGGTTATTTCCCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References