Detailed information of TA system TA151762

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 585364..586214
• Replicon: plasmid p_unnamed1
• Accession: NZ_CP049914
• Organism: Vibrio sp. HDW18

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9KM94
• Locus tag: G7083_RS14505
• Protein ID: WP_000118351.1
• Coordinates: 585364..585897 (-)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: G7083_RS14510
• Protein ID: WP_001909340.1
• Coordinates: 585894..586214 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7083_RS14475	580556..580876	+	321	WP_166013944.1	IS66 family insertion sequence element accessory protein TnpB	-
G7083_RS14480	580873..581226	+	354	WP_166013945.1	IS66 family insertion sequence element accessory protein TnpB	-
G7083_RS14485	581286..582815	+	1530	WP_166013947.1	IS66 family transposase	-
G7083_RS14490	583142..584005	-	864	WP_206212131.1	DUF2971 domain-containing protein	-
G7083_RS14495	584154..585215	-	1062	WP_142577356.1	hypothetical protein	-
G7083_RS14505	585364..585897	-	534	WP_000118351.1	GNAT family N-acetyltransferase	Toxin
G7083_RS14510	585894..586214	-	321	WP_001909340.1	DUF1778 domain-containing protein	Antitoxin
G7083_RS14515	586386..587024	-	639	WP_069217094.1	hypothetical protein	-
G7083_RS14520	587217..587498	-	282	WP_001100053.1	hypothetical protein	-
G7083_RS14525	587654..588013	-	360	WP_166015490.1	VOC family protein	-
G7083_RS14530	588178..588711	-	534	WP_139283082.1	hypothetical protein	-
G7083_RS14540	588884..589243	-	360	Protein_534	HNH endonuclease	-
G7083_RS14545	589798..590298	-	501	WP_033929164.1	NAD(P)H-dependent oxidoreductase	-
G7083_RS14550	590446..590961	-	516	WP_166015491.1	ClbS/DfsB family four-helix bundle protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	hlyA	1..599487	599487
	-	inside	Integron	catB9	hlyA	3..599486	599483

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (97-153)

Antitoxin

• Vibrio phage ICP1, Orf50 (22-98)

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 20171.46 Da
• Isoelectric Point: 9.1432

>T151762 WP_000118351.1 NZ_CP049914:c585897-585364 [Vibrio sp. HDW18]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Nucleotide

• Length: 534 bp

>T151762 NZ_CP065700:c2490254-2490150 [Atlantibacter hermannii]
GGCAAGGCGATTTCAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATA
CAGGAATCGTATTCGGTCTTTTTTT

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11759.53 Da
• Isoelectric Point: 4.9309

>AT151762 WP_001909340.1 NZ_CP049914:c586214-585894 [Vibrio sp. HDW18]
MAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFM
AACNKVKAPNQALLEAVKFTEKSGIK

Nucleotide

• Length: 321 bp

>AT151762 NZ_CP065700:2490143-2490314 [Atlantibacter hermannii]
AAAAGATAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTGAAATCGCCTTGCCCTTTAAGAATAGATTACGATGTCAGGTTTTCCAGTCCGCGACAAAAGT
GGTTCAAAAAAA

Structures

Toxin

• AlphaFold DB: Q9KM94