Detailed information of TA system TA151759

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc(toxin)
• Location: 556921..557492
• Replicon: plasmid p_unnamed1
• Accession: NZ_CP049914
• Organism: Vibrio sp. HDW18

Toxin (Protein)

• Gene name: doc
• Uniprot ID: Q9KMA2
• Locus tag: G7083_RS14260
• Protein ID: WP_000351248.1
• Coordinates: 556921..557322 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: G7083_RS14265
• Protein ID: WP_166015532.1
• Coordinates: 557322..557492 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7083_RS14240	553086..555092	+	2007	WP_166015474.1	cellulase family glycosylhydrolase	-
G7083_RS14245	555277..556427	+	1151	WP_166015475.1	IS3 family transposase	-
G7083_RS14250	556442..556699	-	258	WP_206212130.1	hypothetical protein	-
G7083_RS15025	556688..556818	-	131	Protein_482	acetyltransferase	-
G7083_RS14260	556921..557322	-	402	WP_000351248.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
G7083_RS14265	557322..557492	-	171	WP_166015532.1	acetyltransferase	Antitoxin
G7083_RS14270	557683..558096	-	414	WP_166015476.1	VOC family protein	-
G7083_RS14275	558281..558598	-	318	WP_001232701.1	HigA family addiction module antidote protein	-
G7083_RS14280	558609..558758	-	150	WP_166015477.1	type II toxin-antitoxin system RelE/ParE family toxin	-
G7083_RS14285	558812..559120	+	309	WP_166013938.1	IS66 family insertion sequence element accessory protein TnpB	-
G7083_RS14290	559162..559461	+	300	WP_166013939.1	IS66 family insertion sequence element accessory protein TnpB	-
G7083_RS14295	559551..561055	+	1505	Protein_490	IS66 family transposase	-
G7083_RS14300	561091..561827	-	737	Protein_491	transposase	-
G7083_RS14305	561917..562216	-	300	WP_166013939.1	IS66 family insertion sequence element accessory protein TnpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	hlyA	1..599487	599487
	-	inside	IScluster/Tn	-	-	555277..564970	9693
	-	inside	Integron	catB9	hlyA	3..599486	599483

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (1-132)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14608.71 Da
• Isoelectric Point: 4.0128

>T151759 WP_000351248.1 NZ_CP049914:c557322-556921 [Vibrio sp. HDW18]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Nucleotide

• Length: 402 bp

>T151759 NZ_CP065699:4900672-4901094 [Serratia plymuthica]
GTGGCCCAGTGGCGATGTAATGTCCGCATTTCCTGGCGCACCCAGCTACTCTCGCTGCTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTACGGCCCGATCTGGCTGGTGTTGTTGACGCTGGTGGTATTTGAATGCA
TCCGCAGCCAAAAGCGCATTGCGTCGCGGCAGGGCGAACTGCGTCTGCTGGCGAATAAGCGTTTAAGTTGGCACGGACAG
GAATGGTTGCTGGCAAAGCAACCCTGGATGCCGCGTTACGGCATTTTGCTGACGCTGCAGCCGACGCAGGGCAAAAAACG
CCGCCGGCTATGGCTGGCCTCCGACAGCATGGGCAAAGCCGAATGGCGGCATCTGCGCCAGTTGTTGCTGCACCCGTCGG
CCGATGATGACGAGGAACCCTGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6335.44 Da
• Isoelectric Point: 10.7591

>AT151759 WP_166015532.1 NZ_CP049914:c557492-557322 [Vibrio sp. HDW18]
MNRKVEAYGVYAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Nucleotide

• Length: 171 bp

>AT151759 NZ_CP065699:4900425-4900691 [Serratia plymuthica]
ATGGATATTAATAATAAAGCACGTATTCACTGGGCCTGCCGCCGTGGCATGCGTGAGCTGGATATCTCAATCATGCCGTT
CTTCGAGCATGAGTACGACCAGTTGAATGACACAGACAAAGCGTTGTTTATCCGCCTGCTTGAGAGCGACGATCCCGATC
TGTTCAACTGGTTGATGAATCATGGCGCTCCGCAAGACAGTGAACTGCAGAGAATGGTGACACTGATCCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTAA

Structures

Toxin

• AlphaFold DB: A0A0Q0PN34