Detailed information of TA system TA151758

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 468041..468581
• Replicon: plasmid p_unnamed1
• Accession: NZ_CP049914
• Organism: Vibrio sp. HDW18

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A151JGK8
• Locus tag: G7083_RS13850
• Protein ID: WP_000277238.1
• Coordinates: 468041..468310 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: G7083_RS13855
• Protein ID: WP_166015409.1
• Coordinates: 468303..468581 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7083_RS13820	463202..464212	-	1011	WP_166015407.1	APC family permease	-
G7083_RS13825	464393..464599	-	207	Protein_398	transposase domain-containing protein	-
G7083_RS13830	464691..465731	+	1041	WP_166013940.1	IS21 family transposase	-
G7083_RS13835	465718..466479	+	762	WP_166013941.1	IS21-like element helper ATPase IstB	-
G7083_RS13840	466635..467132	-	498	WP_166015408.1	GNAT family N-acetyltransferase	-
G7083_RS13845	467129..467401	-	273	WP_000246254.1	DUF1778 domain-containing protein	-
G7083_RS13850	468041..468310	-	270	WP_000277238.1	type II toxin-antitoxin system YafQ family toxin	Toxin
G7083_RS13855	468303..468581	-	279	WP_166015409.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
G7083_RS13865	468838..469185	+	348	WP_000885699.1	DUF3024 domain-containing protein	-
G7083_RS13870	469395..470108	+	714	WP_000123659.1	Fic family protein	-
G7083_RS13875	470329..470496	+	168	Protein_407	type II toxin-antitoxin system RelE/ParE family toxin	-
G7083_RS13880	470533..472037	-	1505	Protein_408	IS66 family transposase	-
G7083_RS13885	472127..472426	-	300	WP_166013939.1	IS66 family insertion sequence element accessory protein TnpB	-
G7083_RS13890	472468..472776	-	309	WP_166015410.1	IS66 family insertion sequence element accessory protein TnpB	-
G7083_RS13895	472797..473408	-	612	WP_166014981.1	IS630 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	hlyA	1..599487	599487
	-	inside	Integron	catB9	hlyA	3..599486	599483
	-	inside	Integron	-	-	467129..470508	3379

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-84)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10406.11 Da
• Isoelectric Point: 9.5084

>T151758 WP_000277238.1 NZ_CP049914:c468310-468041 [Vibrio sp. HDW18]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Nucleotide

• Length: 270 bp

>T151758 NZ_CP065699:c4205849-4205571 [Serratia plymuthica]
GTGACACTCAAGTGGACGGAACCCGCAATTGCCGATCGTATAGCAATTTATGACTACCTGGAAACAAAGAATCCGGCCGC
AGCTATAGAAATTGATAGCTTGATTTCAGCAACTGCGACACGACTCTCACAAAACCCGTCCAGTGGAAAACCAGGTCGAG
TGCCCGGTACACGTGAAATGGTTATTCATCATTCCTATTTTCTGGTTTATGAATTAATCAACGGGTTAATCATTATGCTG
GCCGTAGTTCATGCCCGCCGTCAGTGGCCCGCCAATTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10160.60 Da
• Isoelectric Point: 5.1069

>AT151758 WP_166015409.1 NZ_CP049914:c468581-468303 [Vibrio sp. HDW18]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAETVEAM
LNELTEDKVQHV

Nucleotide

• Length: 279 bp

>AT151758 NZ_CP065699:c4206142-4205873 [Serratia plymuthica]
ATGTCTGAATCTACCGTGGTTATCCGAGTGGATGAGGAATTAAAAATCGCCTTTGCCAGCGCTGCCAAAGCAGCCGATCG
CACCGCATCTCAGTTGCTGCGCGATTTCATGCGTGATTTTGTCAGCCGGCAAACTCATCAGAAAGAGTATGAGCAGTGGC
TACAGGAAAAAGTGGACTTAAGCCGTAAAGCGCTTAATGAAGGAAAAATCACTGATAATGAAGCCGTTGAGGCCTACTTC
GCTGAACGTAGATCAAAACTGATAAGGTAA

Structures

Toxin

• AlphaFold DB: A0A151JGK8