Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 466635..467401 Replicon plasmid p_unnamed1
Accession NZ_CP049914
Organism Vibrio sp. HDW18

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag G7083_RS13840 Protein ID WP_166015408.1
Coordinates 466635..467132 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag G7083_RS13845 Protein ID WP_000246254.1
Coordinates 467129..467401 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7083_RS13815 462415..463068 + 654 WP_166015406.1 GTP cyclohydrolase I FolE -
G7083_RS13820 463202..464212 - 1011 WP_166015407.1 APC family permease -
G7083_RS13825 464393..464599 - 207 Protein_398 transposase domain-containing protein -
G7083_RS13830 464691..465731 + 1041 WP_166013940.1 IS21 family transposase -
G7083_RS13835 465718..466479 + 762 WP_166013941.1 IS21-like element helper ATPase IstB -
G7083_RS13840 466635..467132 - 498 WP_166015408.1 GNAT family N-acetyltransferase Toxin
G7083_RS13845 467129..467401 - 273 WP_000246254.1 DUF1778 domain-containing protein Antitoxin
G7083_RS13850 468041..468310 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
G7083_RS13855 468303..468581 - 279 WP_166015409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
G7083_RS13865 468838..469185 + 348 WP_000885699.1 DUF3024 domain-containing protein -
G7083_RS13870 469395..470108 + 714 WP_000123659.1 Fic family protein -
G7083_RS13875 470329..470496 + 168 Protein_407 type II toxin-antitoxin system RelE/ParE family toxin -
G7083_RS13880 470533..472037 - 1505 Protein_408 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - hlyA 1..599487 599487
- inside Integron catB9 hlyA 3..599486 599483
- inside Integron - - 467129..470508 3379


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-89)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18615.34 Da        Isoelectric Point: 8.4465

>T151757 WP_166015408.1 NZ_CP049914:c467132-466635 [Vibrio sp. HDW18]
MMNTVLLDKDKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSTYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKCFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T151757 NZ_CP065699:c3314049-3312727 [Serratia plymuthica]
ATGCGTCGTTCGCAACAACGGTTAGCTATCTGGATGAATGGTATTCCGGTGGGGTACTGGGAAAAGCGCAAAGGTGAAGA
TCGGCTGGAATATCTGCCTGACTGGATTGCAGATAGCCAGGGGCGACCTTTGTCGCTTTCTTTGCCTTTCACGCCGGGGA
ATCAGCCTTACCGCGGCAGTGTAGTGCGCGATTATTTCGATAACCTGCTGCCGGATAGCGGGGGGATCCGTCGACGTTTG
GCAATGCGTTATCATGCCGAAAGCCTTGATCCCTTTGATTTACTGACTGAACTGGGCCGCGACTGTGTGGGCGCCATACA
ACTTCTTGATACTGATGAGCAACCCTCCCATATATTTTCCATCAGGCAGCGCCCGCTTTCAGAGGCACAAATTGCCGAGA
GGCTCCGCAATACCGCCACGATGTTACCGGGGCGACAGGATCAGGATGACGATCTACGCCTATCCATCGCCGGCGCTCAA
GAAAAAACAGCGCTGTTGTGGCACGACGACCAGTGGTGTTTACCTGAGGGAAATACGCCGACCACGCATATATTTAAATT
AGCGCTGGGGCTGGTGGGGAATATGCGGGCCGATATGAGCACGTCCACCGAGAATGAATGGCTCTGTTCTCTGATTCTTG
AACACTATGGTGTACCGGTAGCAAGAACCCATATTGCGCAGTTTGAAGATCAAAAGGCGCTGATCGTTGAGCGTTTTGAC
AGGAAGCTATCGAGTGATAGGCAGTGGTGGATCCGCCTGCCGCAAGAGGATATGTGCCAGGCTCTGGGCGTTTCGCCGCT
GAAGAAGTATCAGTCAGACGGTGGTCCCGGTATTACAGATATTATGGAAGTTCTGAGTCGCTCGGATCAGGCTGAAACAG
ATCGCAGGCACTTCTTTAAAGCGCAGATTATTTTTTGGTTGCTGGCCGCGACCGATGGTCACGCAAAGAATTGCAGTCTT
GCGCATTTACCGCAAAATCGTTACCACCTGACGCCCCTGTACGATGTGCTATCGGCCTGGCCGCTGATTGGCCCGGGGAA
TAGCCAGATAGCCTGGCAGAAGTGCAAACTGGCAATGGCCGTTCGCGGGAGCAGTAATTATTACCACATTAGCCAGATCC
GACGCCGCCACTGGATAAAACACGGTGAAATAACCGGGTTAGGCCAACAGGAGGTTGAATCCATTATTGAAGAGCTGCTG
GCGGTAACCCCGGGAGTTATTGATCGTGTCGCGGAACTGCTGCCTGAGCAGTTCCCACCAGAATTAGCGGCATGCATTTT
TGATGGTATCAGGCAGCAGTGTGCGCGGTTGGCAGGGAAATAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9685.19 Da        Isoelectric Point: 6.2988

>AT151757 WP_000246254.1 NZ_CP049914:c467401-467129 [Vibrio sp. HDW18]
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT151757 NZ_CP065699:c3314350-3314054 [Serratia plymuthica]
ATGAATACCGTCTATCCGTTAAAAACATTGAGCCAGCTACGCCCTTTACTGGTGGGTTTTCGTAAAGCGAAAGGTCTGAC
GCAAAAAGACGTCTCTGAAAGGCTGGGCGTCACCCAGCAGACCTATGCACGCCTGGAGTCAAACCCTGCTTCAGCCAGCC
TGGAACGCCTGTTTCGGGTGTTTAATGTGCTGGGCATTGAAGTGGTGCTTTCCTCAGAGCTCACCTCTCCGGGATGTGAA
ACGGAGGATACTTCTACAACTCATATAGACTCGCCCGCTAGGCGGGAACAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References