Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 2822..3320 Replicon plasmid p_unnamed1
Accession NZ_CP049914
Organism Vibrio sp. HDW18

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag G7083_RS11840 Protein ID WP_000589156.1
Coordinates 3054..3320 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag G7083_RS11835 Protein ID WP_000643598.1
Coordinates 2822..3067 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7083_RS11820 528..707 - 180 WP_114781153.1 DUF645 family protein -
G7083_RS11825 1009..1656 - 648 WP_166015058.1 hypothetical protein -
G7083_RS11830 1802..2677 - 876 WP_052702531.1 hypothetical protein -
G7083_RS11835 2822..3067 - 246 WP_000643598.1 hypothetical protein Antitoxin
G7083_RS11840 3054..3320 - 267 WP_000589156.1 BrnT family toxin Toxin
G7083_RS11845 3597..3974 + 378 WP_166015059.1 PEGA domain-containing protein -
G7083_RS11855 4130..5959 - 1830 WP_166015060.1 AAA family ATPase -
G7083_RS11860 6117..6695 - 579 WP_166015061.1 hypothetical protein -
G7083_RS11865 6834..7832 - 999 WP_166015062.1 FRG domain-containing protein -
G7083_RS11870 7966..8238 - 273 WP_166015063.1 DUF4282 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - hlyA 1..599487 599487
- inside Integron catB9 hlyA 3..599486 599483


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T151756 WP_000589156.1 NZ_CP049914:c3320-3054 [Vibrio sp. HDW18]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T151756 NZ_CP065699:c3288787-3288437 [Serratia plymuthica]
ATGTGGACTGTAATAACAACGGAAGAGTTTGATCGGTGGTTTGCGGTGCAGGATGAACTTACGCAGGAGAAAGTGCTGGC
TGCATTAGTATTGCTTGAGCGGAGTGACCCCAACCTCTCACGTCCTTTTGTAGACTCGTTGAGAGGGTCACAGCACCCTA
ATATGAAAGAACTGCGGGTTCAGCATAAAGGGCGGCCGATTCGCGCTTTTTTTGCCTTTGACTCACTACGTCAGGCTATT
GTTTTGTGTGCCGGCGATAAGACCGGTAACGAGAAGCGGTTTTACAAAGTCATGCTGCCTATTGCTGATGCGCAGTTTAC
CCAGCATTTGATGTGTAATTTTAAGGAGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT151756 WP_000643598.1 NZ_CP049914:c3067-2822 [Vibrio sp. HDW18]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT151756 NZ_CP065699:c3288433-3288134 [Serratia plymuthica]
ATGGGTACTTTAAAAGACATGCTAGCCTCGCGTACCCCGGAGAGTCTGCAACGAATCGAAGAAATGGCGCAAGAAATGTG
GCTGGAAGCACGGTTGTACCAATTGCGTGAGGCGCTGAATATCTCACAGCAGGAACTGGCGAATAATCTGGGTATCTCCC
AGCCTTCCGTCGCGGCGATAGAGCAGCGTGGCAATGAGCTGAAGATATCGACATTGAAGCGCTATGTGGAAGCCATGGGC
GGAACTCTGCGGCTGGATGTCGAGCTGCCGGACGGCAAGCACGTCGGATTTAGAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References