Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1089316..1089964 Replicon chromosome
Accession NZ_CP049913
Organism Vibrio sp. HDW18

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag G7083_RS05235 Protein ID WP_166014991.1
Coordinates 1089563..1089964 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag G7083_RS05230 Protein ID WP_166013864.1
Coordinates 1089316..1089549 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7083_RS05195 1085473..1086762 + 1290 WP_166013861.1 phosphoribosylamine--glycine ligase -
G7083_RS05200 1086962..1087210 - 249 Protein_966 type II toxin-antitoxin system PemK/MazF family toxin -
G7083_RS05205 1087227..1087838 - 612 WP_166014981.1 IS630 family transposase -
G7083_RS05210 1087792..1088262 - 471 WP_166013741.1 IS630 family transposase -
G7083_RS05215 1088325..1088429 - 105 Protein_969 type II toxin-antitoxin system PemK/MazF family toxin -
G7083_RS05220 1088429..1088683 - 255 WP_166013862.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
G7083_RS05225 1088821..1089120 - 300 WP_166013863.1 tyrosine-type recombinase/integrase -
G7083_RS05230 1089316..1089549 + 234 WP_166013864.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
G7083_RS05235 1089563..1089964 + 402 WP_166014991.1 type II toxin-antitoxin system VapC family toxin Toxin
G7083_RS05240 1090243..1090935 - 693 WP_166013865.1 DUF1481 domain-containing protein -
G7083_RS05245 1090984..1091256 - 273 WP_166013866.1 DNA-binding protein HU-alpha -
G7083_RS05250 1091558..1092199 - 642 WP_166013867.1 OmpA family protein -
G7083_RS05255 1092398..1093684 - 1287 WP_166013868.1 TadG -
G7083_RS05260 1093687..1094226 - 540 WP_166013869.1 ATP-binding protein -
G7083_RS05265 1094207..1094704 - 498 WP_166013870.1 pilus assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

SpoVT-AbrB domain

(7-48)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14863.39 Da        Isoelectric Point: 7.8037

>T151755 WP_166014991.1 NZ_CP049913:1089563-1089964 [Vibrio sp. HDW18]
MLDTCICSFIMRENPITVLEKLQAVVSKQHRIVISAITYQEMQYGLLGKKASQKHAVLVAEFLKRIDEIMPWDKLAVDAT
TKVKRDLMAKGTPIGDNDTAIAGHAIAAGCVLVTNNTREFQRVEGLKLEDWVH

Download         Length: 402 bp

>T151755 NZ_CP065699:2904663-2904953 [Serratia plymuthica]
GTGCCACAACTGATATGGACGCCAGCGGCGCTGCTGGATGTACAGCGGCTTTATCGATTTCTGGCTGAGAAGGATCTCAA
TTCGGCAAAGCGCGCTGTCGCCACTATTCGTAACTGCATCAAAATAATAGCGCACCAACCCCATATTGGCCGCCCCGCTA
AAGATATGGCACCTGAATTCAGGGAGTGGCCTATCGATTTCGGCAATAGCGGTTATCTTGTTCTGTATCGGTTTAACGGT
GTAACCGCCGTTATTTTGGCTATTCGCCACCAAAGCGAAACCGGGTATTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8992.07 Da        Isoelectric Point: 4.6286

>AT151755 WP_166013864.1 NZ_CP049913:1089316-1089549 [Vibrio sp. HDW18]
MRTVSIFKNGKNQAVRLPKDFEFDGVNELEIHKEGDVITLRPARPDWLSYGQFEKADSDFMVERQTVVPDEGRFNFE

Download         Length: 234 bp

>AT151755 NZ_CP065699:2904397-2904675 [Serratia plymuthica]
ATGGCTACTGCTACGTCGATAAAAATTGATGATGAGCTTAAACAACGGGTGCAACACATTGCCGCGGCCCACCAGCGCAG
CGCACACTGGATTATGCGTGAAGCTATTCGTGAATATGTCGAGCGTGAAGAAAAACGCGAGGCTGTTCGCAACGATGCAT
TACAGGCATGGGAAACCTATCAGGCCAATGGTAAACATTTGACTCAGGACGAGGCTGACGGCTGGCTCTCCGATCTGGAA
AAAGGTGATGATACGGAGATACCCGGGTGCCACAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References