Detailed information of TA system TA151751

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF-MazE
• Location: 5104400..5104968
• Replicon: chromosome
• Accession: NZ_CP049905
• Organism: Diaphorobacter sp. HDW4B

Toxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: G7048_RS23320
• Protein ID: WP_166070419.1
• Coordinates: 5104400..5104720 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: G7048_RS23325
• Protein ID: WP_166070420.1
• Coordinates: 5104714..5104968 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7048_RS23300	5099518..5099955	-	438	WP_166070415.1	DUF1311 domain-containing protein	-
G7048_RS23305	5100051..5101574	-	1524	WP_166070416.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-
G7048_RS23310	5101717..5102628	+	912	WP_166070417.1	LysR family transcriptional regulator	-
G7048_RS23315	5102903..5104357	+	1455	WP_166070418.1	D-serine/D-alanine/glycine transporter	-
G7048_RS23320	5104400..5104720	-	321	WP_166070419.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
G7048_RS23325	5104714..5104968	-	255	WP_166070420.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
G7048_RS23330	5105201..5106634	+	1434	WP_166070421.1	multidrug transporter subunit MdtD	-
G7048_RS23335	5106651..5108504	-	1854	WP_166070422.1	ABC transporter ATP-binding protein/permease	-
G7048_RS23340	5108721..5108996	-	276	WP_166070423.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 11760.86 Da
• Isoelectric Point: 10.4752

>T151751 WP_166070419.1 NZ_CP049905:c5104720-5104400 [Diaphorobacter sp. HDW4B]
MVKRGEIWVINLDPTIGSEIQKTRPCVIVSPADLHDHLRTVIVAPMTSLGFAAPFRVPVTHDGKKGLIVLDQLRSVDQAR
LVRKAGSLPSKTLDEVLLRLQEIFAR

Nucleotide

• Length: 321 bp

>T151751 NZ_CP065699:c634154-633972 [Serratia plymuthica]
GTGAAAAGTGCAGAACTGATCAGGCTGTTAGAACGGGAAGGTTGGGTTTTAGAGCGGATAAAGGGAAGCCACCATCAGTT
CAAACACCCGAGATCCCGTCTGGTGATCACCGTTCCACACCCGCGTAAAGATCTGAAGCCGGGAACGCTGCGCCAAATCA
TGAAAGATGCCGGGCTGTGCTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 8871.09 Da
• Isoelectric Point: 4.2958

>AT151751 WP_166070420.1 NZ_CP049905:c5104968-5104714 [Diaphorobacter sp. HDW4B]
MEIAIRNIGNSKGIVLPKSLLAQAGLEGEAVADVLLEDGAIVLRKPSKPSRAGWAEAAKAIAAQDEDKLLMGEFPNADDA
ENTW

Nucleotide

• Length: 255 bp

>AT151751 NZ_CP065699:c633942-633529 [Serratia plymuthica]
ATGTTTTACCCTGCTTATGTACATTCAGACTACGACGGCAGCGCCAGCGGTTTCTTCCCCGATGTGCCGGGCTGTTATTT
TGCCGGCGACACCCTCGATAAAGCCTTTGAAGATGCCAAAGGCGCGCTGGACGCGCATTTCGAACTTCTGAGCGAAGACA
ACCAGGCCATCCCGCGGCCACAGGCCGTTTCCTTCCATCTGGCACAGGAAAACGACGCCCTGAACGGCGGACAGTGGCTG
CTGGTCGATATCAATATGGATAAGTTCGATGGGCGGGCGGAACGTATAAATATCACCCTGCCGCACCGCTTGCTGAACCG
CATCGATTCACTGGTGCAGCGGCATCCTGGCTATGGGAGCCGCAGCGCCTTTTTGGCCGCAGCCGCCCGTAATGAATTAT
TGAAAGTCGATTAG