Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 5104400..5104968 Replicon chromosome
Accession NZ_CP049905
Organism Diaphorobacter sp. HDW4B

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G7048_RS23320 Protein ID WP_166070419.1
Coordinates 5104400..5104720 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G7048_RS23325 Protein ID WP_166070420.1
Coordinates 5104714..5104968 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7048_RS23300 5099518..5099955 - 438 WP_166070415.1 DUF1311 domain-containing protein -
G7048_RS23305 5100051..5101574 - 1524 WP_166070416.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
G7048_RS23310 5101717..5102628 + 912 WP_166070417.1 LysR family transcriptional regulator -
G7048_RS23315 5102903..5104357 + 1455 WP_166070418.1 D-serine/D-alanine/glycine transporter -
G7048_RS23320 5104400..5104720 - 321 WP_166070419.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G7048_RS23325 5104714..5104968 - 255 WP_166070420.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
G7048_RS23330 5105201..5106634 + 1434 WP_166070421.1 multidrug transporter subunit MdtD -
G7048_RS23335 5106651..5108504 - 1854 WP_166070422.1 ABC transporter ATP-binding protein/permease -
G7048_RS23340 5108721..5108996 - 276 WP_166070423.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11760.86 Da        Isoelectric Point: 10.4752

>T151751 WP_166070419.1 NZ_CP049905:c5104720-5104400 [Diaphorobacter sp. HDW4B]
MVKRGEIWVINLDPTIGSEIQKTRPCVIVSPADLHDHLRTVIVAPMTSLGFAAPFRVPVTHDGKKGLIVLDQLRSVDQAR
LVRKAGSLPSKTLDEVLLRLQEIFAR

Download         Length: 321 bp

>T151751 NZ_CP065699:c634154-633972 [Serratia plymuthica]
GTGAAAAGTGCAGAACTGATCAGGCTGTTAGAACGGGAAGGTTGGGTTTTAGAGCGGATAAAGGGAAGCCACCATCAGTT
CAAACACCCGAGATCCCGTCTGGTGATCACCGTTCCACACCCGCGTAAAGATCTGAAGCCGGGAACGCTGCGCCAAATCA
TGAAAGATGCCGGGCTGTGCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8871.09 Da        Isoelectric Point: 4.2958

>AT151751 WP_166070420.1 NZ_CP049905:c5104968-5104714 [Diaphorobacter sp. HDW4B]
MEIAIRNIGNSKGIVLPKSLLAQAGLEGEAVADVLLEDGAIVLRKPSKPSRAGWAEAAKAIAAQDEDKLLMGEFPNADDA
ENTW

Download         Length: 255 bp

>AT151751 NZ_CP065699:c633942-633529 [Serratia plymuthica]
ATGTTTTACCCTGCTTATGTACATTCAGACTACGACGGCAGCGCCAGCGGTTTCTTCCCCGATGTGCCGGGCTGTTATTT
TGCCGGCGACACCCTCGATAAAGCCTTTGAAGATGCCAAAGGCGCGCTGGACGCGCATTTCGAACTTCTGAGCGAAGACA
ACCAGGCCATCCCGCGGCCACAGGCCGTTTCCTTCCATCTGGCACAGGAAAACGACGCCCTGAACGGCGGACAGTGGCTG
CTGGTCGATATCAATATGGATAAGTTCGATGGGCGGGCGGAACGTATAAATATCACCCTGCCGCACCGCTTGCTGAACCG
CATCGATTCACTGGTGCAGCGGCATCCTGGCTATGGGAGCCGCAGCGCCTTTTTGGCCGCAGCCGCCCGTAATGAATTAT
TGAAAGTCGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References