Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 488773..489410 | Replicon | chromosome |
| Accession | NZ_CP049904 | ||
| Organism | Bacillus velezensis strain GB03 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G4NU33 |
| Locus tag | V753_RS02500 | Protein ID | WP_003156187.1 |
| Coordinates | 489060..489410 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | I2HMS5 |
| Locus tag | V753_RS02495 | Protein ID | WP_003156188.1 |
| Coordinates | 488773..489054 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| V753_RS02475 (485138) | 485138..485737 | - | 600 | WP_007609579.1 | rhomboid family intramembrane serine protease | - |
| V753_RS02480 (485830) | 485830..486195 | + | 366 | WP_007609580.1 | holo-ACP synthase | - |
| V753_RS02485 (486360) | 486360..487367 | + | 1008 | WP_007410230.1 | outer membrane lipoprotein carrier protein LolA | - |
| V753_RS02490 (487484) | 487484..488653 | + | 1170 | WP_007609581.1 | alanine racemase | - |
| V753_RS02495 (488773) | 488773..489054 | + | 282 | WP_003156188.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
| V753_RS02500 (489060) | 489060..489410 | + | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| V753_RS02505 (489528) | 489528..490349 | + | 822 | WP_003156182.1 | STAS domain-containing protein | - |
| V753_RS02510 (490354) | 490354..490719 | + | 366 | WP_007609584.1 | RsbT antagonist protein RsbS | - |
| V753_RS02515 (490722) | 490722..491123 | + | 402 | WP_003156178.1 | anti-sigma regulatory factor | - |
| V753_RS02520 (491135) | 491135..492142 | + | 1008 | WP_007609589.1 | PP2C family protein-serine/threonine phosphatase | - |
| V753_RS02525 (492206) | 492206..492535 | + | 330 | WP_003156176.1 | anti-sigma factor antagonist RsbV | - |
| V753_RS02530 (492532) | 492532..493014 | + | 483 | WP_007609591.1 | anti-sigma B factor RsbW | - |
| V753_RS02535 (492980) | 492980..493768 | + | 789 | WP_003156171.1 | RNA polymerase sigma factor SigB | - |
| V753_RS02540 (493768) | 493768..494370 | + | 603 | WP_007410234.1 | PP2C family serine/threonine-protein phosphatase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T151749 WP_003156187.1 NZ_CP049904:489060-489410 [Bacillus velezensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T151749 NZ_CP065695:c3666968-3666588 [Delftia acidovorans]
ATGAATCCCGTTCTGGTCGATACCTCGGTCTGGATCGATCACTTCAGGCAGGGCAATCCTCACCTGGTGCAGCTGCTGCA
GCAAGACATGACGCTCATGCACCCCCTGGTGCTGGGCGAACTGGCCTGCGGCACGCCACCGGCACGCGCACGCACGCTCG
CAGACCTTCAACGGCTCAAGCCTGCCCGGCAGGCCAGCATGCGCGAAGTGATGGCCTTGATAGAGCGCGAGCAGCTCTTT
GGTCTGGGCTGCGGCCTGGTGGACATGACGCTCCTGGCCTCGGCACTCATGTCTTCAGGCGCCAGCCTGTGGTCGCTGGA
CAAGCGCCTGCACGCGCTGGCCCAGCGGTTTGGCATTGCCTACCGTCCCACAGGCCAGTAG
ATGAATCCCGTTCTGGTCGATACCTCGGTCTGGATCGATCACTTCAGGCAGGGCAATCCTCACCTGGTGCAGCTGCTGCA
GCAAGACATGACGCTCATGCACCCCCTGGTGCTGGGCGAACTGGCCTGCGGCACGCCACCGGCACGCGCACGCACGCTCG
CAGACCTTCAACGGCTCAAGCCTGCCCGGCAGGCCAGCATGCGCGAAGTGATGGCCTTGATAGAGCGCGAGCAGCTCTTT
GGTCTGGGCTGCGGCCTGGTGGACATGACGCTCCTGGCCTCGGCACTCATGTCTTCAGGCGCCAGCCTGTGGTCGCTGGA
CAAGCGCCTGCACGCGCTGGCCCAGCGGTTTGGCATTGCCTACCGTCCCACAGGCCAGTAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10562.92 Da Isoelectric Point: 6.4706
>AT151749 WP_003156188.1 NZ_CP049904:488773-489054 [Bacillus velezensis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT151749 NZ_CP065695:c3667168-3666965 [Delftia acidovorans]
ATGAGAACCACGGTCACCATCGACGACGCCTTGTACGAGGAAGCGCTGGAGCTGGCGGAGCCAGAAATGGACAAGGCCGA
CCTGTTTCGCGAAGCCGTCAAGACTTTCGTGAGAGTGCAGGCGGCCAAGCGCCTGGCCGCGCTGGGAGGCAGCGCACCGG
ACATGCGGGAGATTCCCCGTCGCCCACAGGGCATCGAGCCATGA
ATGAGAACCACGGTCACCATCGACGACGCCTTGTACGAGGAAGCGCTGGAGCTGGCGGAGCCAGAAATGGACAAGGCCGA
CCTGTTTCGCGAAGCCGTCAAGACTTTCGTGAGAGTGCAGGCGGCCAAGCGCCTGGCCGCGCTGGGAGGCAGCGCACCGG
ACATGCGGGAGATTCCCCGTCGCCCACAGGGCATCGAGCCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|