Detailed information of TA system TA151745

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 2868178..2868941
• Replicon: chromosome
• Accession: NZ_CP049885
• Organism: Acidovorax sp. HDW3

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: G7045_RS13275
• Protein ID: WP_166160064.1
• Coordinates: 2868447..2868941 (+)
• Length: 165 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: G7045_RS13270
• Protein ID: WP_166160063.1
• Coordinates: 2868178..2868450 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7045_RS13255	2863811..2865772	-	1962	WP_166160060.1	molecular chaperone HtpG	-
G7045_RS13260	2865937..2866872	-	936	WP_166160061.1	exopolyphosphatase	-
G7045_RS13265	2866958..2867536	-	579	WP_166160062.1	TMEM165/GDT1 family protein	-
G7045_RS13270	2868178..2868450	+	273	WP_166160063.1	DUF1778 domain-containing protein	Antitoxin
G7045_RS13275	2868447..2868941	+	495	WP_166160064.1	GNAT family N-acetyltransferase	Toxin
G7045_RS13285	2869413..2870093	-	681	WP_166160065.1	response regulator	-
G7045_RS13290	2870130..2872424	-	2295	WP_166160066.1	HAMP domain-containing protein	-
G7045_RS13295	2872421..2873074	-	654	WP_166160067.1	DUF4390 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (29-148)

Antitoxin

• Vibrio phage ICP1, Orf50 (6-80)

Sequences

Toxin

Protein

• Length: 165 a.a.
• Molecular weight: 17839.58 Da
• Isoelectric Point: 10.2341

>T151745 WP_166160064.1 NZ_CP049885:2868447-2868941 [Acidovorax sp. HDW3]
MSLKLSAPIPLAAPHILDDFACGEASLDEWLKRRALTNQLSGASRSFVVTDKEGRVYGYYAMAAGAVSHQAATSNVRRNM
PDPVPVMVLARLAVDHRAQGIKLGAALLQDAVNRAVAVSQNAGVRALLVHALHDRARQFYAHYGFQESPQHPMTLMLRLN
TVKA

Nucleotide

• Length: 495 bp

>T151745 NZ_CP065695:2021509-2021790 [Delftia acidovorans]
ATGGCGATCACTTCCTTCAAGTGCCCGGAAACCCAGCGCCTGTTCACCAGCGGCAAGACCCGCCGGTTCGCCAACATCCA
GAGCGTGGCGGAGCGCAAGCTGGCTCAGTTGGATGCGGCTGTGACACTTGAATTTCTGCGCAGCCCTCCTGGCAATCGCC
TGGAAATGCTCGTGGGAGATCGGCAGGGCCAGCACAGCATCCGCATCAACGACCAGTGGCGCGTCTGCTTTGTCTGGACG
GAAAAGGGAGTGGCTGACGTAGAGATAGTGGATTACCACTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9843.31 Da
• Isoelectric Point: 5.0175

>AT151745 WP_166160063.1 NZ_CP049885:2868178-2868450 [Acidovorax sp. HDW3]
MRDAAINLRALPEQRDLIDHAASLLGKNRSDFMLEAACDRAQTVVLDQVFFSLDAEKFKQFTAMLDAPPGPNPGLERLMA
VKAPWSTGAA

Nucleotide

• Length: 273 bp

>AT151745 NZ_CP065695:2021869-2022180 [Delftia acidovorans]
ATGCTTAAAAACGGCATGCGCCCCATACACCCAGGTGAAGTCCTGCGCGAGGACTACCTGAAGCCCATGGACATGAGCGC
CAACGCGCTGGCCAGGCACCTGCACGTTCCCGCCTCGCGCGTGAACGACATCGTGCTGGAGCGGCGCGGCATCACGGCCG
ACACGGCGCTGCGGCTGAGCCGCTTCTTTGGGGGCGACGCCCAGTCCTGGCTGAACCTTCAGACCGCCTACGACCTGCGC
ACGGCAGAGCTGAACGCGGAGTTGCAGGCGTCCGTGAGGCAAGTTCATCCGATGCAGCTGCATACCGCCTGA