Detailed information of TA system TA151743

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1390841..1391514
• Replicon: chromosome
• Accession: NZ_CP049885
• Organism: Acidovorax sp. HDW3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G7045_RS06190
• Protein ID: WP_166158772.1
• Coordinates: 1390841..1391263 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G7045_RS06195
• Protein ID: WP_166158774.1
• Coordinates: 1391260..1391514 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7045_RS06180	1385849..1387969	-	2121	WP_166158768.1	DEAD/DEAH box helicase	-
G7045_RS06185	1387966..1390743	-	2778	WP_166158770.1	N-6 DNA methylase	-
G7045_RS06190	1390841..1391263	-	423	WP_166158772.1	type II toxin-antitoxin system VapC family toxin	Toxin
G7045_RS06195	1391260..1391514	-	255	WP_166158774.1	plasmid stabilization protein	Antitoxin
G7045_RS06200	1391610..1392596	-	987	WP_166158776.1	MobA/MobL family protein	-
G7045_RS06205	1392819..1393133	+	315	WP_166158778.1	hypothetical protein	-
G7045_RS06210	1393200..1394621	-	1422	WP_166158780.1	AAA family ATPase	-
G7045_RS06215	1394939..1395262	-	324	WP_166158782.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1282959..1512757	229798

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 14761.25 Da
• Isoelectric Point: 5.1229

>T151743 WP_166158772.1 NZ_CP049885:c1391263-1390841 [Acidovorax sp. HDW3]
MILLDTNVMSEPLRQAPEPRVIEWIDAQAMETLFLSAITVAELRAGVALLPTGKRRAGLQENLEKRVLPLFAGRVLPFDL
ACTQAYAALMAKARGAGLAVATADGYIAAIAAANGFAVATRDISPFEAAGVTVINPWALA

Nucleotide

• Length: 423 bp

>T151743 NZ_CP065695:1495265-1495561 [Delftia acidovorans]
ATGTACAGCGTCATCGAAACCGAGGCGTTTGCTGATTGGGTAGACAGCATTCGTGACATACCAACTCGTATCCGCCTGCG
TCGTCGCCTGGGCAAAGCCATGCGCGGAAACCTGGGAGACGTGAAATCCGTTGGCGAGGGCCTATGGGAGATGCGCGAGT
TTTTTGGGCCAGGTTGGCGCATGTACTACATCCAACGCGATCATGTTCTGATCGTGATGCTTGGCGGCGGAGACAAGTCC
AGCCAGGCACAGGACATTGCTGCGGCCAGGGCGATGGCCAGGGAGATCAAGCTATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9406.79 Da
• Isoelectric Point: 7.2063

>AT151743 WP_166158774.1 NZ_CP049885:c1391514-1391260 [Acidovorax sp. HDW3]
MAMLTVRNISEEVHRALRVRAAQHGQSMEAEVREILESAISPKGRVKLGSLLADMGRQAKLSDEEFAVFEQVRDKTPARP
VSFE

Nucleotide

• Length: 255 bp

>AT151743 NZ_CP065695:1495558-1495854 [Delftia acidovorans]
ATGAGCAACATCAAGATGCGGCCATTCGACATGGCCAACTACCTCGGCACCGAAGAGGAAATCGTGGAGTACCTGCGCCA
GGCGCTGGAAGACAACGATCCGGCCGAACTGGCTGCGGCGCTGGGCGACATCGCACGCGCGCGCGGCATGACTCAGCTCG
CTCGCGACACCGGACTTTCTCGGGAAAGCCTCTACAAAAGCCTGTCTGGCGAACGGGCGCCCAGTTCCGAGACGCTGTTC
AAGGTGATTCAGGCCATGGGCTTCAGGCTCACCATCGCTCCTGCCGCATCGCAGTAG