Detailed information of TA system TA151742

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 499473..501018
• Replicon: chromosome
• Accession: NZ_CP049885
• Organism: Acidovorax sp. HDW3

Toxin (Protein)

• Gene name: HipA1
• Uniprot ID: -
• Locus tag: G7045_RS02240
• Protein ID: WP_166156694.1
• Coordinates: 499723..501018 (+)
• Length: 432 a.a.

Antitoxin (Protein)

• Gene name: HipB1
• Uniprot ID: -
• Locus tag: G7045_RS02235
• Protein ID: WP_166156692.1
• Coordinates: 499473..499733 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7045_RS02220	495625..496629	+	1005	WP_166156688.1	IS481 family transposase	-
G7045_RS02225	496736..497557	-	822	WP_166156689.1	IS21-like element ISThsp19 family helper ATPase IstB	-
G7045_RS02230	497547..499091	-	1545	WP_166156690.1	IS21 family transposase	-
G7045_RS02235	499473..499733	+	261	WP_166156692.1	helix-turn-helix transcriptional regulator	Antitoxin
G7045_RS02240	499723..501018	+	1296	WP_166156694.1	type II toxin-antitoxin system HipA family toxin	Toxin
G7045_RS02250	501435..501989	+	555	WP_166156696.1	transcription elongation factor GreB	-
G7045_RS02255	501993..504254	-	2262	WP_166156698.1	bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase	-
G7045_RS02260	504333..504536	-	204	WP_166156701.1	DNA-directed RNA polymerase subunit omega	-
G7045_RS02265	504557..505177	-	621	WP_166156704.1	guanylate kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	476217..501989	25772

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (11-68)

Sequences

Toxin

Protein

• Length: 432 a.a.
• Molecular weight: 47560.69 Da
• Isoelectric Point: 7.2606

>T151742 WP_166156694.1 NZ_CP049885:499723-501018 [Acidovorax sp. HDW3]
MARELEVWLVAERVGALAMIDGRLNFRYAPDWLSRSDAVGLSSSLPLQAEPFDDHHTRPFFAGLLPEGQLRRLIARQFQV
SSQNDFALLDRIGGECAGAVTLLEPGQPLSILEHDHDVQWLSDEEIVAILDELPHRPMLAGKDGLRLSLAGAQDKLPVVF
DGARIGLPKNGTPSSHILKPAIRTLSGTVTNEGFCLALAEAMQLKPAKSQVRSVLGREFLLVERYDRVVDAQGLRRRLHQ
EDFCQALGVVPEMKYQNEGGPDLALCFDLVRRATRPSAPHILRMLDYVIFNALIGNHDAHAKNFSLLYAGKSAVLAPLYD
VLSTAIYSNLTPKMAMKIGSKYKFSEVQARHWNQFTEAVGLSKAQARKRILSLTNSMPITARALQSDPKRGFSGQGVIEQ
IVLLIEQRCALTAQRLSATTADMEEAPEPST

Nucleotide

• Length: 1296 bp

>T151742 NZ_CP065693:4517320-4517538 [Enterobacter asburiae]
ATGTCTGATAAACCACTCACAAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACGCTTGAGCGCGT
CATTGAAAAGAATAAATATGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAAC
TGACAATGAATAAACTGTATGACAAAATCCCTACTTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 8965.33 Da
• Isoelectric Point: 7.2029

>AT151742 WP_166156692.1 NZ_CP049885:499473-499733 [Acidovorax sp. HDW3]
MRSIQTTVQLGDALRAARKLLGLTQPQLALAAGVGVRFIVDLEAGKTTLRLENVLRVIDALGGTLQLIGLPSSAPDSHPE
GNDHGA

Nucleotide

• Length: 261 bp

>AT151742 NZ_CP065693:4516918-4517292 [Enterobacter asburiae]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCTCAGGATTTGCAAAAATGGCGTAAATCGGGAAATCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTGAGTCTTTCCTGTTAA