Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VapB
Location 2462789..2463399 Replicon chromosome
Accession NZ_CP049863
Organism Leucobacter viscericola strain HDW9C

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G7068_RS10775 Protein ID WP_166291955.1
Coordinates 2463001..2463399 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G7068_RS10770 Protein ID WP_166291953.1
Coordinates 2462789..2463004 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7068_RS10750 2458179..2459795 - 1617 WP_166293131.1 amidohydrolase -
G7068_RS10755 2460201..2460875 + 675 WP_166291947.1 TetR family transcriptional regulator -
G7068_RS10760 2460796..2462259 + 1464 WP_166291949.1 M20/M25/M40 family metallo-hydrolase -
G7068_RS10765 2462263..2462673 - 411 WP_166291951.1 zf-TFIIB domain-containing protein -
G7068_RS10770 2462789..2463004 + 216 WP_166291953.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G7068_RS10775 2463001..2463399 + 399 WP_166291955.1 PIN domain nuclease Toxin
G7068_RS10780 2463408..2464580 - 1173 WP_166291957.1 helix-turn-helix domain-containing protein -
G7068_RS10785 2464736..2466067 + 1332 WP_166291959.1 MFS transporter -
G7068_RS10790 2466126..2467829 + 1704 WP_166291961.1 acetolactate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-39)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14775.04 Da        Isoelectric Point: 4.5070

>T151740 WP_166291955.1 NZ_CP049863:2463001-2463399 [Leucobacter viscericola]
MILVDSSVWIEYLRDSDDPVVEELDRLLMREADVRITEPIIMELLAGATTPLRESRISQLTNGLRVIPIDAAIDYRAAAQ
LFVASLQNGHPLRGLSDCLIAAVAIRGDAVLFHRDRDFKYIAEVAPLRLYGE

Download         Length: 399 bp

>T151740 NZ_CP065693:2576759-2577112 [Enterobacter asburiae]
GTGTGGGCAATTAACACGACGGACAGGTTTGATCGCTGGTTCACTTCGCTTGAGGATACCGATCGCGCCAGCGTACTTGC
AGCACTGCTTGTTTTGCGAGAGAAGGGGCCGGGTTTATCGAGACCCTACGCTGATACGCTTAAAGGCTCTCGTCACAGCA
ACATGAAAGAGCTACGTATTCAGAGTAAGGGCGATCCCTTGAGGGCATTTTTCGCCTTTGATCCAAACCGCACCGGTATC
GTGCTTTGTGCGGGCAATAAGGTCGGCAATGAAAGGCGATTCTACGATGAGATGCTTCTCGTTGCTGACCGGGAATTCAC
TCACTGGCTGAATACATTAAAAGAGAGGGAATAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7883.06 Da        Isoelectric Point: 4.9974

>AT151740 WP_166291953.1 NZ_CP049863:2462789-2463004 [Leucobacter viscericola]
MGRTNIDIDDALVAEVMSRFQVSTKREAVDLALRRLVGVPLTKGFLRDLRGIGWDGDLDAMRDVPVNGVRD

Download         Length: 216 bp

>AT151740 NZ_CP065693:2577117-2577419 [Enterobacter asburiae]
ATGGGAAGAACTCTTGAGCAGCTTATAGCGGATGAAAAGCCGGAGGTTGTCGCCAGCGCTCAGGCGATAGCAACGGATAT
TTTGCTCAACATTCATCTGGCTGAGTTACGTGAGAAAGTACAAAAAACGCAAGTAGAGATGGCGCAGGCTCTGGGTATCA
GGCAGCCTACCGTTGCGGTAATGGAAAAGGCCGGGCGCGATTTGAAACTCTCTTCTCTCAAGCGCTACGTTGAGGCGGCG
GGCGGAAAGCTGCGGCTTGATGTTGAGCTGCCGGATGGCTCGCACTATGAGTTTGTGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References