Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1684706..1685346 Replicon chromosome
Accession NZ_CP049863
Organism Leucobacter viscericola strain HDW9C

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G7068_RS07555 Protein ID WP_205881369.1
Coordinates 1684706..1685086 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G7068_RS07560 Protein ID WP_166290747.1
Coordinates 1685113..1685346 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7068_RS07540 1680642..1682126 - 1485 WP_166290741.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
G7068_RS07545 1682292..1684028 + 1737 WP_166293058.1 PucR family transcriptional regulator -
G7068_RS07550 1684041..1684673 - 633 WP_166290743.1 Maf family protein -
G7068_RS07555 1684706..1685086 - 381 WP_205881369.1 PIN domain-containing protein Toxin
G7068_RS07560 1685113..1685346 - 234 WP_166290747.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
G7068_RS07565 1685525..1686259 - 735 WP_166290749.1 ABC transporter permease -
G7068_RS07570 1686256..1687020 - 765 WP_166290751.1 ABC transporter ATP-binding protein -
G7068_RS07575 1687055..1688386 + 1332 WP_166290754.1 TRAM domain-containing protein -
G7068_RS07580 1688390..1689472 - 1083 WP_166290756.1 hypothetical protein -
G7068_RS07585 1689465..1689884 - 420 WP_166290759.1 PadR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-115)

Antitoxin

SpoVT-AbrB domain

(8-45)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13813.65 Da        Isoelectric Point: 7.2041

>T151738 WP_205881369.1 NZ_CP049863:c1685086-1684706 [Leucobacter viscericola]
VAIALLRRQKGIDLDRFFANSGRLAISTISIEELEFGAYRSAFPERNLKANDELLAQLKIQDFNRYAAAHAAEVRATLAV
RGTPIGSYDSQIAGHARSLGLTVVTGNTREFERVPGLLVENWIGGE

Download         Length: 381 bp

>T151738 NZ_CP065693:1675223-1675633 [Enterobacter asburiae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTGAGCTATACGCCTCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCAGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.03 Da        Isoelectric Point: 4.3360

>AT151738 WP_166290747.1 NZ_CP049863:c1685346-1685113 [Leucobacter viscericola]
MRTKLFFSNKTQAVRLPKEVAFAEGVEEVEIVVVGESRVITPVNRGLEWWFQNGAAVSEDFMLDREQPPVQERDWGE

Download         Length: 234 bp

>AT151738 NZ_CP065693:1674976-1675242 [Enterobacter asburiae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGACGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TGTTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References