Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3241932..3242605 Replicon chromosome
Accession NZ_CP049862
Organism Sanguibacter sp. HDW7

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G7063_RS14615 Protein ID WP_166415037.1
Coordinates 3241932..3242369 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G7063_RS14620 Protein ID WP_166415038.1
Coordinates 3242366..3242605 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7063_RS14585 3237543..3238013 + 471 WP_206188286.1 molybdenum cofactor biosynthesis protein MoaE -
G7063_RS14590 3238072..3238344 - 273 WP_206188170.1 MoaD/ThiS family protein -
G7063_RS14595 3238349..3239395 - 1047 WP_166415407.1 GTP 3',8-cyclase MoaA -
G7063_RS14600 3239559..3240896 + 1338 WP_166415034.1 molybdopterin molybdotransferase MoeA -
G7063_RS14605 3240893..3241378 + 486 WP_166415035.1 cyclic pyranopterin monophosphate synthase MoaC -
G7063_RS14610 3241378..3241854 + 477 WP_166415036.1 MogA/MoaB family molybdenum cofactor biosynthesis protein -
G7063_RS14615 3241932..3242369 - 438 WP_166415037.1 type II toxin-antitoxin system VapC family toxin Toxin
G7063_RS14620 3242366..3242605 - 240 WP_166415038.1 plasmid stability protein Antitoxin
G7063_RS14625 3242704..3243951 - 1248 WP_166415039.1 ThiF family adenylyltransferase -
G7063_RS14630 3243965..3244711 - 747 WP_166415040.1 respiratory nitrate reductase subunit gamma -
G7063_RS14635 3244708..3245310 - 603 WP_166415408.1 nitrate reductase molybdenum cofactor assembly chaperone -
G7063_RS14640 3245493..3247295 - 1803 WP_166415041.1 nitrate reductase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15427.84 Da        Isoelectric Point: 4.6533

>T151737 WP_166415037.1 NZ_CP049862:c3242369-3241932 [Sanguibacter sp. HDW7]
VIVLDTNVLSEAVRPTPAPQVIEWIDAQHVETLYVSVLTVAELRLGLAVLPDGARRSMLTQRLEDEVFPLFEGRVLPVDG
AVALEFARLQAAARSGGMTMPVIDALIAATCSAHRFTLATRNVADFAASGVPLIDPWRAPGASGV

Download         Length: 438 bp

>T151737 NZ_CP065693:946191-946562 [Enterobacter asburiae]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATCGATCTTTTTAATAATCGTGTTGAGGCGGCGGATGCCATTGA
TCGCACGGCGTCGCATAGAGCCATTAGCCTGATCACGTGGATGGAGGTCATGGTGGGTGCGCGCAAGCACGGACATGAAG
CAAAAACGGCGGCTGTGATGGGGGCTTTTGAGATTATTGATATTTCTCGGGATATCGCAGAAAGAAGCGTTTTACTTCGC
GAGAAACATGGGATGAAACTGCCTGATGCCATTATTCTGGCTACTGCTCAGAGCAGAAGTTGCCCGTTAATCTCACGCAA
TACGAAAGACTTTTCGGGCATTACTGGAGTCGTTTCACCTTACCAGCTGTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8315.44 Da        Isoelectric Point: 6.2180

>AT151737 WP_166415038.1 NZ_CP049862:c3242605-3242366 [Sanguibacter sp. HDW7]
MAAMTVRGISDETHRALKLRAAAHGRSAEAEVRAILDAAVADEGRVRLGSLLADIGHAAGGVELEIVRDRTPYEPVNLG

Download         Length: 240 bp

>AT151737 NZ_CP065693:945946-946188 [Enterobacter asburiae]
ATGAGTCTTTCCGCGGATCTTGATATGGGCAGAATTCTGATCGATTTGTCTGATGACGTAATTCAACGACTGGATAATCT
GAAGCAGCTGCGTAACCAACCTCGTGCCGAATTACTGCGTGAAGCAATTGAGCAATATCTCGACCAGCAGAGTTCATCGG
TTATCCGCGATGCGCTTGGCCTGTGGGGAAACCAGCAGGAAGATGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References